Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis

JAMA : the Journal of the American Medical Association
Stacy A JohnsonJames D Douketis

Abstract

In patients with suspected lower extremity deep vein thrombosis (DVT), compression ultrasound (CUS) is typically the initial test to confirm or exclude DVT. Patients with an initial negative CUS result often require repeat CUS after 5 to 7 days. Whole-leg CUS may exclude proximal and distal DVT in a single evaluation. To determine the risk of venous thromboembolism after withholding anticoagulation in patients with suspected lower extremity DVT following a single negative whole-leg CUS result. MEDLINE, EMBASE, CINAHL, LILACS, Cochrane, and Health Technology Assessments databases were searched for articles published from January 1970 through November 2009. Supplemental searches were performed of Internet resources, reference lists, and by contacting content experts. Included studies were randomized controlled trials and prospective cohort studies of patients with suspected DVT and a negative whole-leg CUS result who did not receive anticoagulant therapy, and were followed up at least 90 days for venous thromboembolism events. Two authors independently reviewed and extracted data regarding a single positive or negative whole-leg CUS result, occurrence of venous thromboembolism during follow-up, and study quality. Seven studies we...Continue Reading

Citations

Dec 3, 2014·Radiologic Clinics of North America·Laurence Needleman
Dec 10, 2013·Hematology·Philip Wells, David Anderson
Jun 12, 2013·Expert Review of Cardiovascular Therapy·Marion AndroGrégoire Le Gal
May 11, 2013·Current Medical Research and Opinion·Alex C Spyropoulos, Alexander G G Turpie
Sep 4, 2015·Journal of Thrombosis and Haemostasis : JTH·Jean-Philippe GalanaudJean-Luc Bosson
Jun 19, 2012·La Revue de médecine interne·J-P GalanaudI Quéré
Oct 29, 2011·The Medical Clinics of North America·James M Hunt, Todd M Bull
Nov 5, 2010·Clinics in Chest Medicine·C Gregory ElliottDaniel Adams
Sep 10, 2010·The American Journal of Emergency Medicine·David R VinsonCedric S Irving
Jan 19, 2012·Hämostaseologie·C Riopel, H Bounameaux
Jul 3, 2013·Hämostaseologie·S M Schellong
Nov 16, 2011·Journal of Thrombosis and Haemostasis : JTH·Gualtiero Palareti, S Schellong
Mar 21, 2012·Journal of Thrombosis and Haemostasis : JTH·J P GalanaudA Leizorovicz
Jan 24, 2014·Journal of Thrombosis and Haemostasis : JTH·J-P GalanaudUNKNOWN OPTIMEV-SFMV investigators
Apr 22, 2015·British Journal of Haematology·Kathryn J LangRoopen Arya
Aug 11, 2015·Journal of Chiropractic Medicine·Andrée-Anne MarchandJulie O'Shaughnessy
Mar 24, 2015·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Adam E FleischerValerie L Schade
Jan 30, 2014·Blood·Gualtiero Palareti
Dec 3, 2014·The Journal of Emergency Medicine·Christopher R TainterReuben J Strayer
Apr 30, 2016·Internal and Emergency Medicine·Angelo PorfidiaRaffaele Landolfi
May 26, 2016·Current Atherosclerosis Reports·Gualtiero Palareti, Michelangelo Sartori
Jun 24, 2015·Emergency Medicine Journal : EMJ·Daniel HornerRichard Body
Sep 24, 2010·The New England Journal of Medicine·Lee Goldman, Jeffrey Ginsberg
Jul 5, 2016·Lancet·Marcello Di NisioHarry R Büller
Mar 9, 2017·Intensive Care Medicine·P MayoA Vieillard-Baron
Mar 8, 2017·Journal of Thrombosis and Haemostasis : JTH·J-P GalanaudJ-L Bosson
May 17, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Scott M StevensC Gregory Elliott
Dec 17, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Paul D SteinUNKNOWN Consensus Group
Oct 12, 2010·Vascular Medicine·Henri BounameauxMarc Righini
Mar 27, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Andrew NicolaidesUNKNOWN International Union of Angiology and Union Internationale du Phlebologie
Oct 6, 2018·Internal Medicine Journal·Hannah Stevens, Huyen Tran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.