Risk of diabetes in HIV infected veterans pre- and post-HAART and the role of HCV coinfection

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Adeel A ButtAmy C Justice

Abstract

We examined the association of hepatitis C virus (HCV) infection with diabetes in veterans infected with human immunodeficiency virus (HIV) before and after the institution of highly active antiretroviral therapy (HAART). The role of age, race, liver disease, alcohol, and drug diagnoses upon the risk of diabetes was also determined. Male veterans with HIV who entered care between 1992 and 2001 were identified from the Veterans Affairs (VA) administrative database. Demographic and disease data were extracted. Kaplan-Meier curves were plotted to determine the incidence of diabetes. Unadjusted and adjusted hazards ratios for diabetes were determined using Cox regression method. A total of 26,988 veterans were studied. In multivariate Cox regression analysis, factors associated with a diagnosis of diabetes included increasing age (HR, 1.44 per 10-year increase in age; 95% CI, 1.39-1.49), minority race (African American: HR, 1.35; 95% CI, 1.24-1.48; Hispanic: HR, 1.63; 95% CI, 1.43-1.86), and care in the HAART era (HR, 2.35; 95% CI, 2.01-2.75). There was a significant interaction between care in the HAART era and HCV infection, with HCV infection being associated with a significant risk of diabetes in the HAART era (HR, 1.39; 95% CI...Continue Reading

References

Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CaroniaG J Alexander
Jun 30, 2000·The American Journal of the Medical Sciences·G E AustinJ E Braun
Jun 22, 2001·The Korean Journal of Internal Medicine·J K RyuS Lee
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M E BriggsT L Wright
Feb 21, 2003·The New England Journal of Medicine·Samuel A BozzetteThomas A Louis
Mar 11, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica E JustmanKathryn Anastos
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shawn L FultzUNKNOWN VACS-3 Project Team
May 14, 2003·Journal of Gastroenterology·Motohiro AraoShinichi Kakumu
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea A HowardEllie E Schoenbaum
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shruti H MehtaDavid L Thomas
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shruti H MehtaMark S Sulkowski

❮ Previous
Next ❯

Citations

Mar 1, 2013·Current Diabetes Reports·Sanjay Kalra, Navneet Agrawal
Aug 11, 2005·Current HIV/AIDS Reports·Marshall J Glesby
Apr 16, 2009·Current Infectious Disease Reports·Kelly A Gebo, Amy Justice
Apr 6, 2007·The New England Journal of Medicine·Margaret James Koziel, Marion G Peters
Dec 1, 2011·Sexual Health·Oluwaseun Falade-Nwulia, Chloe L Thio
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruno LedergerberUNKNOWN Swiss HIV Cohort Study
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph L GouletAmy C Justice
Jun 11, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtAmy C Justice
Dec 1, 2006·AIDS Patient Care and STDs·Krisann K OurslerStephen Crystal
Oct 16, 2013·European Heart Journal·Friedrich ThienemannJürgen Kurt Rockstroh
May 16, 2009·AIDS·Adeel A ButtUNKNOWN Veterans Aging Cohort Study
Nov 16, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anne K MonroeRichard D Moore
May 18, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Raj K MedapalliChristina M Wyatt
Sep 29, 2006·Gut·Adeel A ButtC Kent Kwoh
Nov 18, 2006·Drugs & Aging·Kelly A Gebo
Aug 13, 2009·World Journal of Gastroenterology : WJG·Ashwani-K Singal, Bhupinderjit S Anand
Apr 25, 2012·World Journal of Gastroenterology : WJG·Cho NaingMala Maung
Jan 15, 2014·International Journal of Epidemiology·David G DillonUNKNOWN African Partnership for Chronic Disease Research (APCDR)
Sep 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kaku A ArmahUNKNOWN Veterans Aging Cohort Study (VACS) Project Team
Feb 27, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph K LimVincent Lo Re
Jun 18, 2014·Omics : a Journal of Integrative Biology·Lungile SitoleDebra Meyer
Jun 20, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vincent Lo ReTemitope Olufade
Jan 25, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Indira BrarUNKNOWN Minorities and Women's Task Force of Terry Beirn Community Programs for Clinical Research on AIDS
Nov 18, 2008·Journal of Clinical Gastroenterology·Adeel A ButtMelissa Skanderson
Apr 7, 2009·Expert Review of Anti-infective Therapy·Amedeo LonardoPaola Loria
Sep 26, 2008·Journal of Hepatology·Donna L WhiteHashem B El-Serag
Nov 13, 2007·Alimentary Pharmacology & Therapeutics·J R KramerH B El-Serag
Aug 16, 2006·Alimentary Pharmacology & Therapeutics·A A ButtC K Kwoh
Oct 4, 2012·Clinical Physiology and Functional Imaging·Torsten RoedNina Weis
Jul 2, 2009·Journal of Viral Hepatitis·Wendy A HendersonAdeel A Butt
Sep 3, 2005·Gastroenterología y hepatología·J Salmerón
Jul 15, 2015·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Luísa Amado Costa, Ana G Almeida
Apr 8, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Margaret T MayJonathan A C Sterne

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