Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Abimereki D MuzaaleDorry L Segev

Abstract

New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, we compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III followed for a median of 14 years. We used risk associations from multivariable Cox proportional hazards regression to derive cumulative incidence estimates for selected HIV-positive scenarios (no history of diabetes, hypertension, AIDS, or hepatitis C virus coinfection) and compared these estimates with those from similarly selected HIV-negative scenarios. For 40-year-old HIV-positive individuals with health characteristics that were similar to those of age-matched kidney donors, viral load <400 copies/mL, and CD4+ count ≥500 cells/μL, the 9-year cumulative incidence of ESRD was higher than that of their HIV-negative peers, yet still low: 2.5 versus 1.1 per 10 000 among white wome...Continue Reading

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Citations

May 19, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R W Steiner
Aug 4, 2018·Clinical Transplantation·Sarah E Van Pilsum RasmussenChristine M Durand
Sep 14, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ayelet GrupperEugene Katchman
Mar 14, 2020·AIDS·Rebecca N Kumar, Valentina Stosor
May 31, 2018·Transplantation·Jeffrey L VealeThomas D Mone
May 5, 2018·AIDS Care·Sarah E Van Pilsum RasmussenJeremy Sugarman
Jun 1, 2019·Current Transplantation Reports·Luckmini LiyanageChristine M Durand
Jan 21, 2021·World Journal of Surgery·Brian J BoyarskyDorry L Segev
Jan 28, 2021·Annual Review of Medicine·Puja H NambiarChristine M Durand
Jan 12, 2021·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J BranchereauM-O Timsit
Jul 16, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Marcus R PereiraLloyd E Ratner
May 31, 2019·Current Opinion in Organ Transplantation·Brian J BoyarskyChristine M Durand
Dec 11, 2021·Current Opinion in Organ Transplantation·Daniel Glicklich, Rajat Nog

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