PMID: 11899116Mar 20, 2002Paper

Risk of epithelial ovarian cancer in relation to use of antidepressants, benzodiazepines, and other centrally acting medications

Cancer Causes & Control : CCC
Sascha DublinNoel S Weiss

Abstract

An increased risk of ovarian cancer among users of antidepressants and benzodiazepines has been observed in some but not all prior studies. We examined these associations in a population-based case-control study. We identified 314 members of a health maintenance organization (HMO) who were diagnosed with epithelial ovarian cancer between 1981 and 1997, were aged 35-79 years at diagnosis, and had at least 4 years of HMO membership. Up to four controls were selected for each case (n = 790), matched on age, calendar year, and length of HMO membership. Information concerning past medication use was obtained from the computerized pharmacy database, established in 1977. Cases were slightly less likely than controls to have filled two antidepressant prescriptions (primarily for doxepin, amitriptyline, or imipramine) in any 6-month period prior to a reference date set 1.5 years before diagnosis (conditional odds ratio (OR) 0.71, 95% confidence interval (CI) 0.47-1.1), or to have used an antidepressant continuously for 6 months or longer (OR 0.64, 95% CI 0.36-1.1). Cases were less likely than controls to have filled two benzodiazepine prescriptions in 6 months (OR 0.70, 95% CI 0.47-1.0) or to have used benzodiazepines continuously for 6...Continue Reading

Citations

Mar 17, 2010·International Journal of Cancer. Journal International Du Cancer·Jessica ChubakMargaret T Mandelson
Jun 10, 2017·British Journal of Clinical Pharmacology·Lau Caspar ThygesenJesper Hallas
Aug 10, 2017·International Journal of Cancer. Journal International Du Cancer·Lina S MørchSusanne K Kjaer
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Sep 27, 2016·International Journal of Cancer. Journal International Du Cancer·Hong-Bae KimByoungjin Park
Aug 9, 2007·Cancer Causes & Control : CCC·Sengwee TohSonia Hernández-Díaz
Jan 27, 2007·Current Oncology Reports·H Florence Kim, Michael J Fisch
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Oct 7, 2020·Medicina·Tzu-Rong PengYou-Chen Chao
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin StebbingMark Bower
Feb 2, 2013·Life Sciences·Luciana Romina Frick, Maximiliano Rapanelli

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