Risk of ESRD and Mortality in Kidney and Bladder Stone Formers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Tsering DhondupAndrew D Rule

Abstract

Kidney stones have been associated with increased risk for end-stage renal disease (ESRD). However, it is unclear whether there is also an increased risk for mortality and if these risks are uniform across clinically distinct categories of stone formers. Historical matched-cohort study. Stone formers in Olmsted County, MN, between 1984 and 2012 identified using International Classification of Diseases, Ninth Revision codes. Age- and sex-matched individuals who had no codes for stones were the comparison group. Stone formers were placed into 5 mutually exclusive categories after review of medical charts: incident symptomatic kidney, recurrent symptomatic kidney, asymptomatic kidney, bladder only, and miscoded (no stone). ESRD, mortality, cardiovascular mortality, and cancer mortality. Cox proportional hazards models with adjustment for baseline comorbid conditions. Overall, 65 of 6,984 (0.93%) stone formers and 102 of 28,044 (0.36%) non-stone formers developed ESRD over a mean follow-up of 12.0 years. After adjusting for baseline hypertension, diabetes mellitus, dyslipidemia, gout, obesity, and chronic kidney disease, risk for ESRD was higher in recurrent symptomatic kidney (HR, 2.34; 95% CI, 1.08-5.07), asymptomatic kidney (HR,...Continue Reading

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Citations

Dec 27, 2018·Current Opinion in Nephrology and Hypertension·David S Goldfarb
Jul 20, 2019·Reviews on Environmental Health·Fabiana Baggio Nerbass, Roberto Pecoits-Filho
Jan 24, 2020·Current Opinion in Nephrology and Hypertension·Jaime Uribarri
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Feb 4, 2022·Neurourology and Urodynamics·Khushabu KasabwalaSean P Elliott

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