PMID: 15507199Oct 28, 2004Paper

Risk of fetal exposure to tricyclic antidepressants

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC
Shi Wu Wen, Mark Walker


(1) To review the literature on the risk of fetal exposure to tricyclic antidepressants (TCAs). (2) To estimate the frequency of TCA exposure in pregnant women in the Canadian province of Saskatchewan. MEDLINE was searched for English-language papers published from 1953 to 2003, using the key words "tricyclic antidepressants (TCAs)," "amitriptyline," "amoxapine," "clomipramine," "desipramine," "doxepin," "imipramine," "lofepramine," "maprotiline," "nortriptyline," "protriptyline," and "trimipramine." The search was restricted to human studies. To estimate potential exposure to TCAs during pregnancy, data from the outpatient prescription drug database of Saskatchewan, Canada, were analyzed. The number of women of reproductive age (16 to 44 years) with at least 1 prescription of genotoxic TCAs was 3501 in 1977, 2959 in 1991, and 1330 in 1999. Corresponding figures for non-genotoxic TCAs were 3403, 4200, and 5493, respectively. Based on these figures, the rates of prescriptions given to women of reproductive age in any particular calendar year were 1.30% (95% confidence interval [CI], 1.25%-1.35%) for genotoxic TCAs, and 2.32% (95% CI, 2.25%-2.39%) for non-genotoxic TCAs. Prescription of TCAs to women of reproductive age is quite ...Continue Reading

Related Concepts

Abnormalities, Drug-Induced
Tricyclic Antidepressive Agents
Depressive Symptoms
Maternal-Fetal Exchange
Prenatal Exposure Delayed Effects
Drug Prescriptions

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