Risk of gastric cancer development after eradication of Helicobacter pylori

World Journal of Gastrointestinal Oncology
Ka-Shing Cheung, Wai K Leung

Abstract

Helicobacter pylori (H. pylori) infection is the most important risk factor for gastric cancer (GC) development through the Correa's gastric carcinogenesis cascade. However, H. pylori eradication alone does not eliminate GC, as pre-neoplastic lesions (atrophic gastritis, intestinal metaplasia and dysplasia) may have already developed in some patients. It is therefore necessary to identify patients at high-risk for gastric cancer after H. pylori eradication to streamline the management plan. If the patients have not undergone endoscopy with histologic assessment, the identification of certain clinical risk factors and non-invasive testing (serum pepsinogen) can predict the risk of atrophic gastritis. For those with suspected atrophic gastritis, further risk stratification by endoscopy with histologic assessment according to validated histologic staging systems would be advisable. Patients with higher stages may require long-term endoscopic surveillance. Apart from secondary prevention to reduce deaths by diagnosing GC at an early stage, identifying medications that could potentially modify the GC risk would be desirable. The potential roles of a number of medications have been suggested by various studies, including proton pump ...Continue Reading

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Citations

Oct 18, 2018·Journal of the National Cancer Institute·Ka Shing CheungWai K Leung
Jul 12, 2019·World Journal of Gastroenterology : WJG·Ka-Shing CheungWai-Kay Seto
Jul 1, 2020·Terapevticheskiĭ arkhiv·M A Livzan
May 23, 2020·Clinical and Experimental Gastroenterology·Lina ElsalemOsama Aloudat
Oct 24, 2018·Digestive Diseases and Sciences·Liting XiAirong Wu
Nov 6, 2018·World Journal of Gastroenterology : WJG·Li-Ping LiuYu-Min Li
Mar 20, 2019·Therapeutic Advances in Gastroenterology·Ka Shing Cheung, Wai K Leung
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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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