PMID: 8605278Jan 1, 1996Paper

Risk of hepatitis C virus (HCV) transmission by anti-HCV-negative blood components in Austria and Germany

Annals of Hematology
J RiggertM Köhler

Abstract

In order to estimate the residual risk of transfusion-transmitted HCV infection, we have analyzed data from transfusion centers in Austria (Vienna) and Germany (Göttingen) from 1990 to 1995. In Vienna, the seroprevalence (RIBA-confirmed third-generation anti-HCV tests) was 0.28% in first-time donors (FTD) and the incidence of seroconversion in repeat donors (RD) was 0.049 (per 100 person years) from 1994 to 1995. In Göttingen, the prevalence of a PCR-confirmed positive third-generation anti-HCV test was 0.22% in FTDs and the incidence was 0.093 (per 100 persons years). A continuous decline of the rate of anti-HCV-positive donations and donors was observed with first- and second-generation anti-HCV tests in the years 1990-1994. The introduction of the third-generation anti-HCV test resulted in increased numbers of anti-HCV positive repeat donors, mainly due to false-positive results. Only 9% of anti-HCV-positive repeat donors were either PCR positive or RIBA positive or or indeterminate. Based on a mathematical model which takes (a) the window period, (b) the false-negative rate of anti-HCV tests, and (c) human and operational errors into consideration, we have calculated the residual risk of HCV infection. We used a window peri...Continue Reading

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Citations

May 10, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M WilhelmiA Haverich
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A SchirrenG R Pape
Jan 1, 1997·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J J Lefrère
Aug 13, 2005·Acta Psychiatrica Scandinavica·G ManfrediR Tatarelli
May 1, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fatma M SheblLaurence S Magder
Mar 26, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Idania Gonzalez-PerezRosa Lydia Solís
Nov 24, 2011·Archives of Virology·Wilhelm JelkmannGiovanni P Martelli
Jan 26, 1999·European Journal of Haematology·A C MoorA Brand

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