Risk of hepatocellular carcinoma in Danish outpatients with alcohol-related cirrhosis.

Journal of Hepatology
Peter JepsenHendrik Vilstrup

Abstract

Accurate estimates of hepatocellular carcinoma (HCC) risk in patients with cirrhosis are important to guide surveillance strategies. We described HCC risk among outpatients with alcohol-related cirrhosis and contrasted the risk of death from HCC with the risk of death from variceal bleeding or trauma. This was a nationwide, registry-based historical cohort study between 2006 and 2018. We included all Danish outpatients with a hospital diagnosis of alcohol-related cirrhosis, except those with cancer, those with chronic viral hepatitis or autoimmune liver disease, and those older than 80 years. We followed them through 2018 and described the cumulative risk of HCC and the cumulative risk of death from HCC, variceal bleeding, or trauma. Of the 4,553 patients included, 181 developed HCC and 2,274 died. The cumulative risk of HCC was 0.9% (95% CI 0.7-1.3) after 1 year, 3.6% (95% CI 3.0-4.2) after 5 years, and 6.0% (95% CI 5.1-7.0) after 10 years, or approximately 0.7% per year. Male sex, older age, and decompensated cirrhosis predicted a higher HCC risk. After 10 years, 6.9% of deaths in the cohort could be attributed to HCC, whereas 6.5% could be attributed to variceal bleeding, and 5.0% to trauma. In 2006-2018, Danish outpatients ...Continue Reading

Citations

Jan 10, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hannes HagströmJonas F Ludvigsson
Mar 17, 2021·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Angelo Sangiovanni, Massimo Colombo
Dec 17, 2020·Journal of Hepatology·Anton L V AvanceñaJessica L Mellinger
May 29, 2021·Seminars in Immunopathology·Dirk Schmidt-ArrasStefan Rose-John
Nov 22, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicole J Kim, George N Ioannou

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