Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case-Control Study in Australia

Drugs -- Real World Outcomes
Michael J LeachElizabeth Roughead

Abstract

Few studies have assessed the risk of hip fracture following concurrent use of psychoactive medicines, and none has investigated combinations with selective serotonin reuptake inhibitors. To assess the risk of hip fracture in older people as a result of concurrent use of selective serotonin reuptake inhibitors and other psychoactive medicines. A matched case-control design was employed. Cases were Australian Government Department of Veterans' Affairs beneficiaries aged over 65 years who experienced a hip fracture between 2009 and 2012. Each case was matched with up to four randomly selected controls of the same age (±2 years) and sex. Medicine-hip fracture associations were estimated via conditional logistic regression. The relative excess risk due to interaction (RERI) was calculated to determine whether combined effects differed from the sum of individual effects. There were 8828 cases and 35,310 controls. The median age of subjects was 88 years and 63% were women. The risk of hip fracture was elevated for all medicines assessed individually, most notably selective serotonin reuptake inhibitors (initiation: odds ratio [OR] = 2.7, 95% confidence interval [CI] 2.1, 3.6) and opioids (initiation: OR = 2.3, 95% CI 1.9, 2.9). Combi...Continue Reading

References

Sep 1, 1992·Epidemiology·D W Hosmer, S Lemeshow
Jul 2, 2003·American Journal of Epidemiology·Richard HubbardAnne Tattersfield
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Jan 27, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bahi TakkoucheMahyar Etminan
Jun 27, 2007·Archives of Internal Medicine·Susan J DiemKristine E Ensrud
Jul 17, 2007·Lancet·Louise MalletAllen Huang
May 6, 2008·International Journal of Epidemiology·Sander Greenland
Sep 4, 2008·Neurology·K E EnsrudUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Sep 17, 2008·American Journal of Epidemiology·Mirjam J KnolMatthias Egger
May 6, 2009·Australian and New Zealand Journal of Public Health·Agnes VitryJohn Barratt
Oct 23, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M E L ArbouwF de Vries
Sep 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Q WuM D Crowell
May 25, 2013·Pharmacoepidemiology and Drug Safety·Anton Pottegård, Jesper Hallas
Jul 17, 2013·Journal of the American Geriatrics Society·Shih-Wei LaiKuan-Fu Liao
Apr 17, 2015·Pharmacoepidemiology and Drug Safety·Michael J LeachElizabeth E Roughead
Dec 15, 2015·Journal of the American Geriatrics Society·Shih-Wei LaiKuan-Fu Liao
Feb 6, 2017·Journal of the American Medical Directors Association·Shih-Chang HungShih-Wei Lai

❮ Previous
Next ❯

Software Mentioned

Rx
SAS
Risk - V

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.