Risk of hippocampal metastases in small cell lung cancer patients at presentation and after cranial irradiation: a safety profile study for hippocampal sparing during prophylactic or therapeutic cranial irradiation

International Journal of Radiation Oncology, Biology, Physics
Vijayananda KundapurVinai Gondi

Abstract

Neurocognitive impairment (NI) in patients with small cell lung cancer (SCLC) after whole brain radiation treatment (WBRT) is a significant cause of morbidity. Hippocampal avoidance (HA) during WBRT may mitigate or prevent NI in such patients. However, this has not been tested in SCLC patients. The estimated risk of metastases in the HA region (HM) in patients with SCLC at diagnosis or after WBRT is unknown. Our study aimed to determine the risk of HM in patients with SCLC and to assess correlated clinical factors. Patients with SCLC who experienced brain metastases (BM) at presentation (de novo) or after WBRT treated at the Saskatoon Cancer Centre between 2005 and 2012 were studied. Relevant neuroimaging was independently reviewed by a neuroradiologist. HM was defined as metastases within 5 mm of the hippocampus. Logistic regression analysis was performed to assess correlation between various clinical variables and HM. Seventy eligible patients were identified. Of 59 patients presenting with de novo BM, 3 patients (5%, 95% confidence interval [CI]: 0%-10.7%) had HM. Collectively there were 359 (range, 1-33) de novo BM with 3 (0.8%, 95% CI: 0%-1.7%) HM deposits. Twenty patients experienced progression of metastatic disease in t...Continue Reading

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Citations

Sep 8, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Maingon
Aug 16, 2019·Current Opinion in Oncology·Riccardo SoffiettiRoberta Rudà
Oct 21, 2017·Oncotarget·Rimas V LukasRavi Salgia
Apr 28, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N Rodriguez de DiosA Rodríguez
Jun 8, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F BartelJ Belderbos
Aug 8, 2020·Frontiers in Oncology·Michael C TjongAlexander V Louie
Jan 9, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·N S VoonN Yahya
Aug 12, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Núria Rodríguez de DiosJosé Luis López-Guerra

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