Risk of impaired glucose tolerance in normal weight hirsute women during four years observation

Acta Obstetricia Et Gynecologica Scandinavica
Magdalene AndriesMarianne Andersen

Abstract

Hirsutism is a common disorder affecting 5-20% of women in reproductive age. Only limited follow-up data exist regarding the prognosis for glucose tolerance and metabolic risk factors in hirsutism. Sixty-nine Caucasian hirsute women underwent a clinical examination and an oral glucose tolerance test (OGTT) during 1997-2002 (baseline) and during 2003-2004 (re-evaluation). The observation period was (median; range) 4 (2-7) years. During re-evaluation, body mass index (BMI) was 24.9 (22.4-29.0) kg/m(2) and total Ferriman-Gallwey score was 10 (7-15) (median; 25-75% quartile). The women had unchanged BMI compared to baseline but increased fasting and 2 hour glucose levels. Impaired OGTT outcome during follow-up was seen in 14/66 (21.2%) women, 5/66 (7.6%) developed diabetes. Women who took oral contraceptives had a significantly decreased area under the curve (AUC) for insulin during follow-up, whereas AUC glucose levels increased. The present data supported a high risk of diabetes in only moderately overweight hirsute women.

Citations

Sep 8, 2016·European Journal of Endocrinology·Dorte Glintborg, Marianne Andersen
Aug 9, 2018·Diabetes/metabolism Research and Reviews·Małgorzata Jacewicz-Święcka, Irina Kowalska
Oct 24, 2020·Journal of Clinical Medicine·Małgorzata Jacewicz-Święcka, Irina Kowalska

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