Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study

The Journal of Clinical Endocrinology and Metabolism
Ji-Yeon LeeYong-Ho Lee

Abstract

The risk for dementia among subjects who are obese with normal metabolic profiles, or called metabolically healthy obese (MHO), remains uninvestigated. To determine the association between late-life metabolic health and obesity status and risk of incident dementia. Retrospective cohort study. The National Health Insurance System, Republic of Korea. A total of 12,296,863 adults >50 years old who underwent health examinations from 2009 to 2012 without baseline history of dementia. Incident overall dementia, Alzheimer's disease (AD), and vascular dementia (VaD). Among subjects ≥60 years old, 363,932 (6.4%) developed dementia during a median follow-up of 65 months (interquartile range 51 to 74 months). The MHO group showed the lowest incidence of overall dementia [hazard ratio (HR) 0.85; 95% CI, 0.84 to 0.86] and AD (HR 0.87; 95% CI, 0.86 to 0.88), but not VaD, compared with the metabolically healthy nonobese group. All components of metabolic syndrome except obesity significantly elevated the risk of dementia, and these associations were more pronounced in VaD. In particular, being underweight dramatically increased the risk of dementia. The MHO phenotype in late life demonstrated lower risk of overall dementia and AD but not VaD....Continue Reading

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Citations

Dec 4, 2019·Aging·Ling-Zhi MaAlzheimer's Disease Neuroimaging Initiative
Jun 6, 2020·Scientific Reports·Ji-Sun PaikKyung-Sun Na
Sep 11, 2020·Annals of Clinical and Translational Neurology·Hao HuJin-Tai Yu
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Feb 2, 2021·Journal of Alzheimer's Disease : JAD·Qi-Shuai ZhuangHong-Fang Ji
Jan 1, 2021·International Journal of Molecular Sciences·Thomas Ho-Yin Lee, Suk-Yu Yau
May 28, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Marco ZuinGiovanni Zuliani
Sep 16, 2021·Journal of Obesity & Metabolic Syndrome·Yong-Ho Lee
Jan 12, 2022·The Journal of Clinical Endocrinology and Metabolism·Eugene HanYong-Ho Lee

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