Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury

Journal of Clinical Medicine
Chih-Chung ShiaoVin-Cent Wu

Abstract

The influence of acute kidney injury (AKI) on subsequent incident atrial fibrillation (AF) has not yet been fully addressed. This retrospective nationwide cohort study was conducted using Taiwan's National Health Insurance Research Database from 1 January 2000 to 31 December 2010. A total of 41,463 patients without a previous AF, mitral valve disease, and hyperthyroidism who developed de novo dialysis-requiring AKI (AKI-D) during their index hospitalization were enrolled. After propensity score matching, "non-recovery group" (n = 2895), "AKI-recovery group" (n = 2895) and "non-AKI group" (control group, n = 5790) were categorized. Within a follow-up period of 6.52 ± 3.88 years (median, 6.87 years), we found that the adjusted risks for subsequent incident AF were increased in both AKI-recovery group (adjusted hazard ratio (aHR) = 1.30; 95% confidence intervals (CI), 1.07⁻1.58; p ≤ 0.01) and non-recovery group (aHR = 1.62; 95% CI, 1.36⁻1.94) compared to the non-AKI group. Furthermore, the development of AF carried elevated risks for major adverse cardiac events (aHR = 2.11; 95% CI, 1.83⁻2.43), ischemic stroke (aHR = 1.33; 95% CI, 1.19⁻1.49), and all stroke (aHR = 1.28; 95% CI, 1.15⁻1.43). (all p ≤ 0.001, except otherwise expresse...Continue Reading

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Citations

Apr 17, 2020·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn
Jan 6, 2021·Translational Stroke Research·Simon Fandler-HöflerThomas Gattringer
Oct 8, 2020·Current Opinion in Critical Care·Jay L KoynerJosee Bouchard
Apr 22, 2021·Journal of the American Heart Association·Jia-Jin ChenShao-Wei Chen

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