PMID: 22813717Jul 21, 2012Paper

Risk of insomnia attributable to β-blockers in elderly patients with newly diagnosed hypertension

Drug Metabolism and Pharmacokinetics
Chia-Hsien ChangLi-Jen Lin

Abstract

Use of β-blockers may cause insomnia and central nervous system and/or psychological side effects, but data are limited on the relative risks of insomnia among β-blockers. This retrospective cohort study used Taiwan's National Health Insurance claims database from 2003 to 2007, where 4,063 patients aged above 65 years with newly diagnosed hypertension and treated with β-blockers were followed for 1 year. The primary endpoint was a new insomnia event within 30 days of treatment initiation. Adjusted odds ratios of insomnia were obtained by logistic regressions, controlling for baseline risk factors of insomnia. Using propranolol therapy as the reference, the adjusted odds ratio (95% confidence interval) for the insomnia risk was 0.47 (0.35-0.63) for non-propranolol users, 0.31 (0.19-0.50) for bisoprolol, and 0.46 (0.33-0.66) for atenolol. Compared to the patients using non-selective β-blockers, the adjusted odds ratio was 0.48 (0.36-0.34) for those using selective β(1)-blockers. Additionally, the adjusted odds ratio was 0.72 (0.53-0.96) for β-blockers with low lipophilicity when compared to those with high lipophilicity. The use of bisoprolol and atenolol was associated with the lowest risk of insomnia in elderly patients, as com...Continue Reading

References

Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank
Apr 1, 1990·The American Journal of the Medical Sciences·C Dahlöf, E Dimenäs
Nov 1, 1990·Archives of Internal Medicine·B Q ThiessenU Bergman
Jul 1, 1987·Journal of Clinical Pharmacology·L W NugentJ F Walker
Jan 1, 1985·European Journal of Clinical Pharmacology·W P Koella
Jan 1, 1985·European Journal of Clinical Pharmacology·T A Betts, C Alford
Jan 1, 1985·European Journal of Clinical Pharmacology·J R Cove-Smith, C A Kirk
Mar 1, 1981·The Journal of Pharmacy and Pharmacology·P B Woods, M L Robinson
Mar 25, 2000·Journal of Sleep Research·D LegerM Paillard
Dec 6, 2003·Hypertension·Aram V ChobanianNational High Blood Pressure Education Program Coordinating Committee
Aug 4, 2004·European Heart Journal·José López-SendónTask ForceOn Beta-Blockers of the European Society of Cardiology
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Chin-Hsiao TsengChoon-Khim Chong
Nov 15, 2005·BMJ : British Medical Journal·Jennifer GlassUsoa E Busto
Jun 6, 2006·The American Journal of Medicine·Nabil S Kamel, Julie K Gammack
Aug 18, 2006·Journal of the American Geriatrics Society·Katie L StoneSteven R Cummings
Feb 28, 2008·Journal of Hypertension·Ta-Chen SuChien-Jen Chen
Jun 11, 2008·Clinical Cardiology·Steven G ChrysantBilly Dimas
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Jiu-Chiuan ChenMarcia L Stefanick

Citations

Jan 30, 2014·Annals of Occupational and Environmental Medicine·Yong-Seok HeoHwan-Cheol Kim
Jan 27, 2015·Sleep & Breathing = Schlaf & Atmung·Daniel CaldeiraJoaquim J Ferreira
Jun 7, 2016·Journal of Pharmacological and Toxicological Methods·Simon AuthierMichael J Curtis
Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O D OstroumovaA P Pereverzev

Related Concepts

Adrenergic beta-Antagonists
Antihypertensive Agents
Hypertensive Disease
Transient Insomnia
Retrospective Studies
Incidence Studies
Receptors, Adrenergic, beta-1
Atenolol
Propranolol
Bisoprolol

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.