Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study.

Cancer
Xing XuElham Kharazmi

Abstract

The question of whether having a family history of prostatic borderline or in situ neoplasia (PBISN) is associated with an increased risk of invasive prostate cancer (PCa) or death from PCa remains unanswered. The objective of the current study was to provide an evidence-based risk estimation for the relatives of patients with PBISN. Nationwide Swedish family cancer data sets were used for the current study, including data regarding all residents of Sweden who were born after 1931 and their parents. Standardized incidence ratios (SIRs), standardized mortality ratios (SMRs), and lifetime cumulative risks of PCa were calculated for men with different constellations of family history. Family history was defined as a dynamic (time-dependent) variable considering changes during follow-up (1958-2015). Of the 6,343,727 men in the current study, a total of 238,961 developed invasive PCa and 5756 were diagnosed with PBISN during the follow-up. Men with 1 first-degree relative who was diagnosed with PBISN had a 70% increased risk of invasive PCa (SIR, 1.7; 95% confidence interval, 1.5-1.9) and PCa death (SMR, 1.7; 95% confidence interval, 1.3-2.2) compared with men with no family history of PBISN or invasive PCa. These were rather close ...Continue Reading

References

Apr 15, 1995·American Journal of Epidemiology·A S WhittemoreT Stamey
Mar 27, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·K HemminkiP Mutanen
Oct 9, 2001·Epidemiologic Reviews·K HickeyA Green
Jan 25, 2003·The Journal of Investigative Dermatology·Kari HemminkiKamila Czene
Mar 19, 2003·Lancet·Henrik Grönberg
Apr 9, 2004·The New England Journal of Medicine·Harold J BursteinCarolyn M Kaelin
Apr 13, 2005·International Journal of Cancer. Journal International Du Cancer·Janet R DalingJohn N Krieger
Sep 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HemminkiJ L Bermejo
Jul 26, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki
Sep 4, 2008·Acta Oncologica·Lotti BarlowMats Talbäck
Sep 11, 2008·Journal of the National Cancer Institute·Monica LeuKamila Czene
Jul 31, 2009·International Journal of Cancer. Journal International Du Cancer·Kari HemminkiJan Sundquist
Nov 27, 2009·The Oncologist·Andreas BrandtKari Hemminki
Jan 30, 2010·Cancer Metastasis Reviews·Taichiro IshizumiStephen Lam
Mar 5, 2010·CA: a Cancer Journal for Clinicians·Andrew M D WolfUNKNOWN American Cancer Society Prostate Cancer Advisory Committee
Apr 7, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki
Nov 26, 2011·World Journal of Urology·Kari Hemminki
Dec 22, 2012·BMJ : British Medical Journal·E KharazmiK Hemminki
May 11, 2013·The Journal of Urology·H Ballentine CarterAnthony L Zietman
Aug 12, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tianhui ChenMahdi Fallah
Nov 20, 2014·The Prostate·Frederick AlbrightLisa A Cannon Albright
Jun 16, 2015·Lancet·Gerhardt AttardJohann S de Bono
Oct 7, 2017·European Journal of Epidemiology·Hannah Louise BrookeRickard Ljung
Jan 4, 2018·Annals of Internal Medicine·H Gilbert Welch, Otis W Brawley
Apr 15, 2018·Virchows Archiv : an International Journal of Pathology·Isabella BarthStefan Garczyk
May 23, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Peter H Carroll, James L Mohler
May 26, 2018·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceChien-Wen Tseng
Feb 15, 2019·CA: a Cancer Journal for Clinicians·Carol E DeSantisRebecca L Siegel
Apr 27, 2019·Nature Reviews. Cancer·Sudhir SrivastavaBarnett S Kramer
May 10, 2019·Scandinavian Journal of Public Health·Olof Östergren, Pekka Martikainen
May 10, 2019·World Journal of Oncology·Prashanth Rawla
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki

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