Risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population living in Hong Kong

Japanese Journal of Clinical Oncology
Jeremy Yuen Chun TeohChi-Fai Ng

Abstract

Previous reports on the risk of stroke after androgen deprivation therapy for prostate cancer were largely based on Caucasians. We investigated the risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population. All Chinese prostate cancer patients who were treated primarily with radical prostatectomy or radiotherapy, with (androgen deprivation therapy group) or without (non-androgen deprivation therapy group) further androgen deprivation therapy, at our hospital from year 2000-09 were reviewed. Potential risk factors of ischemic stroke including age, baseline prostate-specific antigen, Gleason score, clinical T stage, hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, history of stroke, use of androgen deprivation therapy and duration of androgen deprivation therapy were reviewed. The risk of ischemic stroke after androgen deprivation therapy was analyzed with Kaplan-Meier and multivariate Cox regression analyses. A total of 452 patients were included, consisting of 200 patients in the non-androgen deprivation therapy group and 252 patients in the androgen deprivation therapy group. The androgen deprivation therapy group appeared to have increased risk of ischemic...Continue Reading

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Citations

Jun 4, 2016·International Urology and Nephrology·Jeremy Yuen Chun Teoh, Chi-Fai Ng
Nov 30, 2018·Asia-Pacific Journal of Clinical Oncology·Jeremy Yuen-Chun TeohDarren Ming-Chun Poon
Dec 14, 2019·Journal of Cardiovascular Translational Research·Chiara Melloni, Adam Nelson
Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Xia LiYan-Hua Shan
Oct 27, 2018·Therapeutic Advances in Drug Safety·M Reza SadaieGary A Thomas

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