Risk of leukaemia in children infected with enterovirus: a nationwide, retrospective, population-based, Taiwanese-registry, cohort study

The Lancet Oncology
Jiun-Nong LinChia-Hung Kao

Abstract

The association between enterovirus infections in children and risk of leukaemia is unclear. We aimed to assess the risk of leukaemia after enterovirus infection in children. We did a nationwide retrospective cohort study by analysing data from the National Health Insurance Research Database (NHIRD) in Taiwan. Children with enterovirus infections aged younger than 18 years were identified. With use of computer-generated random numbers, children not infected with enterovirus were randomly selected and frequency matched (1:1) with children infected with enterovirus by sex, age, urbanisation level, parental occupation, and index year of enterovirus infection. We only included children with complete baseline data for age and sex and who had at least three clinic visits with the diagnosis of enterovirus infection. The diagnosis date of the first clinic visit for the enterovirus infection was defined as the index date for initiation of follow-up person-year measurement and participants. All study patients were followed up until they developed leukaemia, were lost to follow-up, withdrew from the NHI programme, or until the end of the study without leukaemia (censored). Our primary endpoint was a diagnosis of leukaemia during follow-up...Continue Reading

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Citations

Sep 1, 2015·The Lancet Oncology·Logan G Spector
Nov 8, 2016·The Lancet Oncology·Tung-Min YuChia-Hung Kao
Apr 1, 2017·Virulence·Julian W Tang, Christopher W Holmes
Aug 24, 2017·The Pediatric Infectious Disease Journal·Ken-Pen WengMing-Fang Cheng
Jan 10, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Je-Ming HuChia-Hung Kao
Feb 6, 2018·European Child & Adolescent Psychiatry·Tomor HarnodChia-Hung Kao
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May 31, 2018·Journal of Neuro-oncology·Chin-An YangJan-Gowth Chang
Oct 17, 2018·Journal of Clinical Medicine·Chien-Cheng HuangHow-Ran Guo
Aug 25, 2019·International Journal of Molecular Sciences·Sheng-Teng HuangHung-Rong Yen
Jan 12, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Mei-Chia ChouJames Cheng-Chung Wei
Nov 2, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Renin ChangYao-Min Hung
Sep 30, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S-Y LinC H Kao

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