Risk of liver cancer among US male veterans with cirrhosis, 1969-1996.

British Journal of Cancer
E C PerssonK A McGlynn

Abstract

Liver cancer incidence rates in the United States have increased for several decades for reasons that are not entirely clear. Regardless of aetiology, cirrhosis is a strong risk factor for liver cancer. As mortality from cirrhosis has been declining in recent decades, it is possible that the risk of liver cancer among persons with cirrhosis has been affected. Data from the US Veterans Affairs medical records database were analysed after adjustment for attained age, race, number of hospital visits, obesity, diabetes, and chronic obstructive pulmonary disease. Hazard ratio (HR) and 95% confidence interval (95% CI) were calculated using Cox proportional hazards modelling. Survival analyses were conducted using age as the time metric and incidence of cirrhosis as a time-dependent covariate. Among 103 257 men with incident cirrhosis, 788 liver cancers developed. The HR of liver cancer was highest among men with viral-related cirrhosis (HR=37.59, 95% CI: 22.57-62.61), lowest among men with alcohol-related cirrhosis (HR=8.20, 95% CI: 7.55-8.91) and intermediate among men with idiopathic cirrhosis (HR=10.45, 95% CI: 8.52-12.81), when compared with those without cirrhosis. Regardless of cirrhosis type, white men had higher HRs than blac...Continue Reading

References

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Citations

Feb 12, 2014·The American Journal of Gastroenterology·Sean F AltekruseKatherine A McGlynn
Jan 12, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·E Christina PerssonKatherine A McGlynn
Nov 28, 2013·Toxicology Mechanisms and Methods·Ricardo Jorge Dinis-OliveiraFélix Carvalho
Jul 30, 2016·Scientific Reports·Sara LauwensFrank Vanhaecke
Jun 18, 2019·Journal of the American Geriatrics Society·Eric JutkowitzJames L Rudolph
Jul 7, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Catherine de MartelSilvia Franceschi
Apr 29, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Peter JepsenHendrik Vilstrup
May 6, 2020·International Journal of Environmental Research and Public Health·Xiao-Min MuJia Feng

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