Risk of Lymphoma in Patients With Inflammatory Bowel Disease Treated With Anti-tumour Necrosis Factor Alpha Agents: A Systematic Review and Meta-analysis

Journal of Crohn's & Colitis
Chen YangShixue Dai

Abstract

The association between anti-tumour necrosis factor alpha agents and the risk of lymphoma in patients with inflammatory bowel disease has already been sufficiently reported. However, the results of these studies are inconsistent. Hence, this analysis was conducted to investigate whether anti-tumour necrosis factor alpha agents can increase the risk of lymphoma in inflammatory bowel disease patients. MEDLINE, EMBASE, and the Cochrane Library were searched to identify relevant studies which evaluated the risk of lymphoma in inflammatory bowel disease patients treated with anti-tumour necrosis factor alpha agents. A random-effects meta-analysis was performed to calculate the pooled incidence rate ratios as well as risk ratios. Twelve studies comprising 285,811 participants were included. The result showed that there was no significantly increased risk of lymphoma between anti-tumour necrosis factor alpha agents exposed and anti-tumour necrosis factor alpha agents unexposed groups (random effects: incidence rate ratio [IRR] = 1.43, 95% CI, 0.91-2.25; P = 0.116; random effects: risk ratio [RR] = 0.83, 95% CI, 0.47-1.48; P = 0.534). However, monotherapy of anti-tumour necrosis factor alpha agents [random effects: IRR = 1.65, 95% CI, ...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jan 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ian D R ArnottJack Satsangi
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 25, 2004·Journal of the American Academy of Dermatology·Amy E AdamsThomas S Kupper
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·Meena ThayuRobert N Baldassano
Jun 30, 2007·Inflammatory Bowel Diseases·Jennifer L Jones, Edward V Loftus
Jul 20, 2007·The New England Journal of Medicine·William J SandbornUNKNOWN PRECISE 1 Study Investigators
Jun 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletJean-Frédéric Colombel
Dec 25, 2008·Inflammatory Bowel Diseases·Jeffrey S HyamsUNKNOWN Pediatric Inflammatory Bowel Disease Collaborative Research Group
Jun 18, 2009·The American Journal of Gastroenterology·Josh MarehbianWilliam J Sandborn
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Corey A SiegelBruce E Sands
Mar 10, 2010·Current Drug Targets·Abderrahim OussalahLaurent Peyrin-Biroulet
Sep 17, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ambrogio OrlandoUNKNOWN Italian Group for the study of Inflammatory Bowel Disease
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Dec 3, 2010·Journal of Crohn's & Colitis·Anne Thai, Thomas Prindiville
Oct 28, 2011·The American Journal of Gastroenterology·Lisa J HerrintonJames E Allison
Oct 12, 2012·Arthritis and Rheumatism·Kevin HaynesUNKNOWN SABER Collaboration
Jan 28, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Parambir S DulaiCorey A Siegel
May 3, 2014·Pharmacoepidemiology and Drug Safety·Florian BeigelThomas Ochsenkühn
Jun 19, 2014·JAMA : the Journal of the American Medical Association·Nynne Nyboe AndersenTine Jess
Aug 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M FallahK Hemminki
Aug 12, 2014·Gastroenterology Clinics of North America·Parambir S Dulai, Corey A Siegel
Aug 8, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jordan AxelradUNKNOWN New York Crohn's and Colitis Organization
May 18, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Stefanos BonovasSilvio Danese

❮ Previous
Next ❯

Citations

Sep 29, 2020·Clinical and Experimental Gastroenterology·Jessica DahmusKofi Clarke
Jul 2, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Michihide TokuhiraMasahiro Kizaki
Feb 18, 2021·Digestive Diseases and Sciences·Alejandro Llanos-CheaHarland S Winter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.