Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Journal of Pediatric Surgery
Olov NorlénLeigh Delbridge

Abstract

The Bethesda classification for cytology is used to classify thyroid nodules into one of six categories, and for each category there is an implied cancer risk and also recommendation for management. Despite lack of data in children, the American thyroid association promotes the use of the same management guidelines as in adults. Our aim was to study the risk of malignancy for each Bethesda class in children with thyroid nodules. We included all patients ≤18years of age that had underwent a thyroid fine needle aspiration (FNA) at one of two centers between January 1998 and July 2013. FNA results were reclassified according to the Bethesda criteria. Histological, repeat cytological, radiological and clinical follow-up were recorded. Fifty-six patients (66 nodules) underwent FNB. Mean age was 13.6 years. Numbers of nodules reported as BI-BVI were 7, 38, 11, 4, 3 and 3, respectively. Follow-up was achieved for 55 (83%) nodules. Twelve (18%) nodules were malignant by histology and revealed papillary (n=7), follicular (n=3) or insular thyroid cancer (n=2), The proportion of nodules with malignancy for BI-BVI was: 0%, 0%, 18%, 100%, 100% and 100%. The rate of malignancy in thyroid nodules in children seems to be higher than reported i...Continue Reading

References

May 27, 2006·Endocrine-related Cancer·M Niedziela
Jun 6, 2008·Archives of Pediatrics & Adolescent Medicine·Andrea CorriasUNKNOWN Study Group for Thyroid Diseases of Italian Society for Pediatric Endocrinology and Diabetology (SIEDP/ISPED)
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Edmund S Cibas, Syed Z Ali
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Constantine G A TheoharisDavid C Chhieng
May 24, 2011·Journal of the American College of Surgeons·John I LewCarmen C Solorzano
Sep 17, 2011·AJNR. American Journal of Neuroradiology·D W KimY M Kim
Dec 21, 2011·Pediatric Blood & Cancer·Antje RedlichPeter Vorwerk
May 19, 2012·Cancer Cytopathology·Sara E MonacoYuri E Nikiforov
Nov 21, 2012·Journal of Clinical Research in Pediatric Endocrinology·Andrea Corrias, Alessandro Mussa
Apr 13, 2013·International Journal of Health Sciences·Shagufta Tahir Mufti, Rihab Molah
May 24, 2013·Annals of Surgical Oncology·Hye Mi GweonJeong-Ah Kim
Jun 6, 2013·The Journal of Clinical Endocrinology and Metabolism·Anjuli GuptaStephen A Huang
Jul 9, 2013·Journal of Cytology·Santosh Kumar MondalSwapan Kumar Sinha
Jul 19, 2013·Acta Cytologica·Matthew SmithSara E Monaco
Nov 16, 2013·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Ningjian WangYingli Lu
Dec 24, 2013·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Blair A WilliamsRobert D Hart
Mar 7, 2014·Journal of Clinical and Diagnostic Research : JCDR·Vidya VasudevGithanjali S

❮ Previous
Next ❯

Citations

Mar 13, 2016·Cancer Cytopathology·Kristen L PartykaHoward H Wu
Jul 15, 2016·Cancer Cytopathology·Elmira AmirazodiJonathan D Wasserman
Jun 28, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael CanfarottaValerie Cote
Sep 14, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Courtney OlmstedGeeta Lal
Feb 16, 2019·Cancer Cytopathology·Huiying WangVivian L Weiss
Jun 30, 2019·Diagnostic Cytopathology·Amer HeiderXin Jing
Jul 13, 2019·Thyroid : Official Journal of the American Thyroid Association·Christine E CherellaAri J Wassner
May 4, 2016·Current Opinion in Pediatrics·Andrew J Bauer, Gary L Francis
Jul 31, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Andrew J Bauer
Nov 18, 2015·Current Opinion in Oncology·Elisabeth T Tracy, Sanziana A Roman
Jan 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rebecca D ChernockYuri E Nikiforov
Apr 8, 2018·Diagnostic Cytopathology·Priya PathakSonal Sharma
Jul 5, 2018·Annals of Pediatric Endocrinology & Metabolism·Joon Ho JangDae Kyun Koh
Jun 15, 2019·Biomolecular Concepts·Hamid Reza HemmatiMajid Foroutan
Jan 29, 2021·Thyroid : Official Journal of the American Thyroid Association·Huy Gia VuongAndrey Bychkov
Mar 13, 2021·Surgical Oncology Clinics of North America·Emily Christison-Lagay, Reto M Baertschiger
Sep 8, 2020·Hormone Research in Pædiatrics·Shruthi AroraJanet Chuang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.