Risk of malignancy in resected pancreatic mucinous cystic neoplasms

The British Journal of Surgery
Margaret G KeaneMarco Del Chiaro

Abstract

Pancreatic mucinous cystic neoplasms (MCNs) are rare mucin-producing cystic tumours defined by the presence of ovarian-type stroma. MCNs have a malignant potential and thus surgery is frequently performed. The aim of this cohort study was to define better the criteria for surgical resection in patients with MCN. This multicentre retrospective study included all resected MCNs between 2003 and 2015 in participating centres. Lesions without ovarian-type stroma were excluded. Patient characteristics, preoperative findings, histopathology findings and follow-up data were recorded. The study included 211 patients; their median age was 53 (range 18-82) years, and 202 (95·7 per cent) were women. Median preoperative tumour size was 55 (range 12-230) mm. Thirty-four of the 211 (16·1 per cent) were malignant, and high-grade dysplasia (HGD) was found in a further 13 (6·2 per cent). One-third of MCNs in men were associated with invasive cancer, compared with 15·3 per cent in women. Five cases of malignant transformation occurred in MCNs smaller than 4 cm. All cases of malignancy or HGD were associated with symptoms or features of concern on preoperative cross-sectional imaging. In multivariable analysis, raised carbohydrate antigen 19-9 (od...Continue Reading

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Citations

Jun 5, 2020·Zentralblatt für Chirurgie·Maximilian BrunnerRobert Grützmann
Sep 19, 2019·Nature Reviews. Gastroenterology & Hepatology·Nadine C M van HuijgevoortMarc G Besselink
Sep 6, 2018·Visceral Medicine·Lianne ScholtenMarco Del Chiaro
Aug 25, 2018·Visceral Medicine·Georg BeyerJulia Mayerle
Apr 4, 2021·Journal of Clinical Medicine·Margaret G Keane, Elham Afghani
Aug 11, 2021·European Radiology·Marie-Pierre VulliermeMaxime Ronot
Jul 9, 2021·Journal of Internal Medicine·Marco Del ChiaroRichard D Schulick
Oct 23, 2021·Gastroenterology·Kjetil Søreide, Giovanni Marchegiani

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