Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Claudia CoppoGiorgio Saracco

Abstract

Patients with chronic hepatitis C have an increased risk of diabetes mellitus but the type and risk of developing diabetes-related complications have not yet been evaluated. In order to compare the incidence of diabetic microangiopathy in patients with new onset diabetes without microangiopathy we recruited 54 hepatitis C virus (HCV)-positive and 119 HCV-negative patients from January 2005 to December 2006. All patients were followed-up every 6 months for liver and diabetic complications and incidence of cardiovascular diseases up to December 2012 when data were retrospectively analyzed. The two cohorts were comparable at enrolment except for mean body mass index, obesity rate and family history of diabetes (p=0.007). After 7.2 years of follow-up, 13 HCV-positive (24.1%) and 37 HCV-negative patients (31%) showed at least one microangiopathic complication (p=0.34); 5 HCV-positive (9.3%) and 13 HCV-negative patients (10.8%) reported cardiovascular diseases (p=0.2); 14 HCV-positive (24.5%) compared to 0 HCV-negative patients developed liver-related complications (p=0.0003). One HCV-positive patient died due to liver cancer, 1 HCV-negative patient died from myocardial infarction (p=0.3). Increasing age (HR=1.04, 95% CI: 1.00-1.07, ...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G BianchiE Pisi
Jul 9, 2002·Journal of Gastroenterology and Hepatology·Andreas HolsteinE-H Egberts
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shruti H MehtaDavid L Thomas
Dec 4, 2003·Journal of Hepatology·Vlad RatziuUNKNOWN LIDO Study Group
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Annalisa BerzigottiMarco Zoli
Aug 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marcello PersicoAchille Iolascon
Jan 12, 2008·Journal of Clinical Biochemistry and Nutrition·Shoko KuriyamaHisataka Moriwaki
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bart J VeldtHarry L A Janssen
Jan 14, 2009·World Journal of Gastroenterology : WJG·Diego Garcia-CompeanHector Maldonado-Garza
Jul 30, 2010·International Journal of Cancer. Journal International Du Cancer·Chao-Hung HungSheng-Nan Lu
Oct 18, 2011·Journal of Infection and Public Health·Wassim ChehadehWidad Al-Nakib
Jan 17, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Chiara GiordaninoGiorgio Saracco
Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yao-Chun HsuChun-Ying Wu
May 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laure ElkriefDominique Valla
Jun 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yi-Wen HuangJia-Horng Kao

❮ Previous
Next ❯

Citations

Nov 29, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ester VanniGiorgio Saracco
Jul 19, 2016·International Journal of Cardiology·Pasquale AmbrosinoMatteo Nicola Dario Di Minno
Dec 12, 2017·Journal of Clinical and Translational Hepatology·Ahmed BabikerShashwatee Bagchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.