Risk of Mortality According to Body Mass Index and Body Composition Among Postmenopausal Women

American Journal of Epidemiology
Jennifer W BeaZhao Chen

Abstract

Obesity, often defined as a body mass index (BMI; weight (kg)/height (m)(2)) of 30 or higher, has been associated with mortality, but age-related body composition changes can be masked by stable BMI. A subset of Women's Health Initiative participants (postmenopausal women aged 50-79 years) enrolled between 1993 and 1998 who had received dual-energy x-ray absorptiometry scans for estimation of total body fat (TBF) and lean body mass (LBM) (n = 10,525) were followed for 13.6 (standard deviation, 4.6) years to test associations between BMI, body composition, and incident mortality. Overall, BMI ≥35 was associated with increased mortality (adjusted hazard ratio (HR) = 1.45, 95% confidence interval (CI): 1.16, 1.82), while TBF and LBM were not. However, an interaction between age and body composition (P < 0.001) necessitated age stratification. Among women aged 50-59 years, higher %TBF increased risk of death (HR = 2.44, 95% CI: 1.38, 4.34) and higher %LBM decreased risk of death (HR = 0.41, 95% CI: 0.23, 0.74), despite broad-ranging BMIs (16.4-69.1). However, the relationships were reversed among women aged 70-79 years (P < 0.05). BMI did not adequately capture mortality risk in this sample of postmenopausal women. Our data suggest...Continue Reading

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Citations

Jul 16, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·J W BeaT G Lohman
Jan 31, 2019·Journal of the American Geriatrics Society·Shawna FollisZhao Chen
Mar 14, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Felipe M de SantanaRosa Mr Pereira
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Jan 16, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicholas C HarveyEugene McCloskey
Jan 28, 2020·Medicine and Science in Sports and Exercise·Mary T ImbodenMatthew P Harber
May 26, 2021·Menopause : the Journal of the North American Menopause Society·Michael G KnightFatima Cody Stanford

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