Risk of mortality and cardiovascular disease associated with the ankle-brachial index: Systematic review

Atherosclerosis
C L HealdAnkle Brachial Index Collaboration

Abstract

To determine the strength and consistency with which a low ankle brachial pressure index (ABI), measured in the general population, is associated with an increased risk of subsequent death and/or cardiovascular events. Systematic review. Medline, Embase, reference lists and grey literature were searched; studies known to experts were also retrieved. All cause mortality, fatal and non-fatal coronary heart disease and stroke. Longitudinal studies in which participants were representative of the general population (all ages, either sex) and which used any standard method for measurement and calculation of the ABI. Studies in which participants were selected according to presence of pre-existing disease or were post intervention (e.g. angioplasty or peripheral arterial grafting) were excluded. 11 studies comprising 44,590 subjects from six different countries were included. Despite clinical heterogeneity between studies, the findings were remarkably consistent in demonstrating an increased risk of clinical cardiovascular disease associated with a low ABI. A low ABI (<0.9) was associated with an increased risk of subsequent all cause mortality (pooled RR 1.60, 95% CI 1.32-1.95), cardiovascular mortality (pooled RR 1.96, 95% CI 1.46-...Continue Reading

References

May 29, 1998·Circulation·P W WilsonW B Kannel
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·A W TsaiD W Jones
Sep 6, 2003·Stroke; a Journal of Cerebral Circulation·M HollanderM M B Breteler

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Citations

Sep 18, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·H I M KälschK Kroeger
May 16, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Frank BeutnerMarkus Scholz
Oct 23, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Key-Chung ParkSung-Hyuk Heo
Feb 8, 2011·Internal and Emergency Medicine·Claudio CimminielloUNKNOWN PANDORA Study Investigators
Nov 19, 2013·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Carlos GuijarroAntonio Hernández-Mijares
Aug 21, 2013·Atherosclerosis·Bethany Barone GibbsKerry J Stewart
Sep 10, 2008·Nature Clinical Practice. Cardiovascular Medicine·Jeffrey W Olin
Jun 2, 2011·Nature Reviews. Cardiology·Joe F LauJeffrey W Olin
Oct 27, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Shih-Chueh ChenMeng-Chih Lee
Nov 21, 2007·Topics in Magnetic Resonance Imaging : TMRI·Tomas HansenLars Johansson
Dec 9, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F PurroyE Fernández
Jun 30, 2010·International Journal of Clinical Practice·K KrögerC Diehm
Sep 3, 2008·BMJ : British Medical Journal·Jackie F PriceUNKNOWN AAA Trialists
Jul 2, 2011·BMC Cardiovascular Disorders·Birgitta SigvantEric Wahlberg
Nov 28, 2012·BMC Surgery·Giuseppe GiuglianoGiovanni Esposito
Oct 24, 2009·Vascular Health and Risk Management·Mo Al-QaisiSam Kaddoura
Mar 17, 2010·Journal of Atherosclerosis and Thrombosis·Liqiang ZhengYingxian Sun
Apr 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Anselm K GittKurt Bestehorn
Jun 11, 2014·BMC Cardiovascular Disorders·Samson OkelloBrian Herb Annex
Nov 29, 2013·Journal of Atherosclerosis and Thrombosis·Po-Chao HsuSheng-Hsiung Sheu
Sep 23, 2014·Techniques in Vascular and Interventional Radiology·Thomas J Ward, Robert A Lookstein
Feb 20, 2013·Current Cardiology Reports·Mary McGrae McDermott
Sep 21, 2013·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Rayford R June, Lisabeth V Scalzi
Jan 8, 2014·Current Cardiovascular Risk Reports·Douglas DardenElizabeth A Jackson
Feb 21, 2009·Journal of Hypertension·Pedro MorillasUNKNOWN Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) Investigators
Mar 30, 2013·The Journal of Nutrition, Health & Aging·B A MuzemboN Suganuma

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