Risk of Multiple Sclerosis in Patients with Psoriasis: A Danish Nationwide Cohort Study

The Journal of Investigative Dermatology
Alexander EgebergPeter Riis Hansen

Abstract

Psoriasis and multiple sclerosis (MS) are inflammatory disorders with similarities in genetic risk variants and inflammatory pathways. Limited evidence is available on the relationship between the two diseases. We therefore investigated the risk of incident (new-onset) MS in patients with mild and severe psoriasis, respectively. All Danish citizens aged ≥18 years from January 1, 1997 to December 31, 2011 were identified by linkage of nationwide registries at the individual level. We estimated incidence rate ratios (IRRs) adjusted for age, gender, socio-economic status, smoking, medication, comorbidity, and ultraviolet phototherapy, by Poisson regression. There were 58,628 and 9,952 cases of mild and severe psoriasis, and 9,713 cases of MS, respectively. Incidence rates (IRs) of MS per 10,000 person years for the reference population, mild psoriasis, and severe psoriasis were 1.78, 3.22, and 4.55, respectively. Adjusted IRRs of MS were 1.84 (95% confidence interval [CI] 1.46 to 2.30), and 2.61 (95% CI 1.44 to 4.74) in mild and severe psoriasis, respectively. Similar results were observed when adjustment for family history of MS was included in the analyses. Psoriasis may confer a disease severity-dependent risk of MS. Further st...Continue Reading

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Citations

Feb 3, 2016·Journal of the American Academy of Dermatology·Alexander EgebergJacob Pontoppidan Thyssen
Mar 15, 2016·The Journal of Allergy and Clinical Immunology·Yuki M F AndersenJacob P Thyssen
Apr 29, 2016·Annals of Neurology·Alexander EgebergJacob P Thyssen
Mar 19, 2016·The Journal of Investigative Dermatology·Peter JensenLone Skov
Jul 4, 2016·The American Journal of Cardiology·Gorm Mørk HansenPeter Riis Hansen
Jun 11, 2016·Journal of the American Academy of Dermatology·Alexander EgebergPeter R Hansen
Jul 22, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergU Mrowietz
Aug 10, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·K M JørgensenJ P Thyssen
Sep 17, 2016·The British Journal of Dermatology·E Sbidian
Oct 16, 2016·Journal of the American Academy of Dermatology·Yuki M F AndersenJacob P Thyssen
Nov 1, 2016·The British Journal of Dermatology·A EgebergJ P Thyssen
Nov 8, 2016·Journal of the American Academy of Dermatology·Alexander EgebergJacob P Thyssen
Jan 23, 2017·The Journal of Sexual Medicine·Alexander EgebergJacob P Thyssen
Oct 9, 2016·The British Journal of Dermatology·E H ModalsliM Saunes
Jan 17, 2017·The Journal of Investigative Dermatology·Alexander EgebergLotus Mallbris
Apr 11, 2017·Journal of the American Academy of Dermatology·Jacob P ThyssenAlexander Egeberg
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Mar 16, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·N GuidoB Nardone
Jun 12, 2017·Journal of the American Academy of Dermatology·Jacob P ThyssenAlexander Egeberg
Jun 25, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergL Skov
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Sep 30, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·P JensenL Skov
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Dec 12, 2017·Cellular & Molecular Immunology·Marta Consuegra-FernándezFrancisco Lozano
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