Risk of Multiple Sclerosis in Patients with Psoriasis: A Danish Nationwide Cohort Study

The Journal of Investigative Dermatology
Alexander EgebergPeter Riis Hansen

Abstract

Psoriasis and multiple sclerosis (MS) are inflammatory disorders with similarities in genetic risk variants and inflammatory pathways. Limited evidence is available on the relationship between the two diseases. We therefore investigated the risk of incident (new-onset) MS in patients with mild and severe psoriasis, respectively. All Danish citizens aged ≥ 18 years from 1 January 1997 to 31 December 2011 were identified by linkage of nationwide registries at the individual level. We estimated incidence rate ratios (IRRs) adjusted for age, gender, socioeconomic status, smoking, medication, comorbidity, and UV phototherapy by Poisson regression. There were 58,628 and 9,952 cases of mild and severe psoriasis, respectively, and 9,713 cases of MS. Incidence rates of MS per 10,000 person-years for the reference population, mild psoriasis, and severe psoriasis were 1.78, 3.22, and 4.55, respectively. Adjusted IRRs of MS were 1.84 (95% confidence interval [CI], 1.46-2.30) and 2.61 (95% CI, 1.44-4.74) in mild and severe psoriasis, respectively. Similar results were observed when adjustment for family history of MS was included in the analyses. Psoriasis may confer a disease severity-dependent risk of MS. Further studies are warranted to ...Continue Reading

Citations

Apr 16, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Usman KhalidPeter Riis Hansen
Oct 9, 2016·The British Journal of Dermatology·E H ModalsliM Saunes
Mar 7, 2018·Reviews in the Neurosciences·Man AmanatNima Rezaei
Dec 17, 2017·The British Journal of Dermatology·M R KamstrupA Egeberg
Jul 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·E DaudenR Rivera
Jun 13, 2018·Advances in Wound Care·Vera B Morhenn
Mar 3, 2019·The Journal of Rheumatology·Hasan Gökcer TekinAlexander Egeberg
May 13, 2020·Expert Review of Clinical Pharmacology·Ya-Chu Tsai, Tsen-Fang Tsai
Sep 18, 2016·The British Journal of Dermatology·P Theut RiisG B Jemec
Aug 10, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·K M JørgensenJ P Thyssen
Mar 16, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·N GuidoB Nardone
Jul 1, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergL Skov
Jan 21, 2018·Journal of the American Heart Association·Usman KhalidPeter R Hansen
Oct 11, 2017·The British Journal of Dermatology·E GaliliN Astman
Nov 2, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C R HamannJ P Thyssen
Apr 29, 2016·Annals of Neurology·Alexander EgebergJacob P Thyssen
Sep 17, 2016·The British Journal of Dermatology·E Sbidian
Jul 1, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·E H ModalsliM Saunes
Mar 10, 2016·The British Journal of Dermatology·A EgebergL Skov
Jun 14, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·G MironA Barzilai
Jun 18, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Masutaka Furue, Takafumi Kadono
Sep 30, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·P JensenL Skov
Apr 5, 2018·Rheumatology Advances in Practice·Alexander EgebergLotus Mallbris
May 5, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C GrodnerM Mezzarobba
Nov 1, 2016·The British Journal of Dermatology·A EgebergJ P Thyssen
Mar 5, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergL Skov
Jun 25, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergL Skov
Feb 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·C R HamannJ P Thyssen
Oct 29, 2017·American Journal of Clinical Dermatology·Mina AminJashin J Wu
Dec 12, 2017·Cellular & Molecular Immunology·Marta Consuegra-FernándezFrancisco Lozano
Aug 10, 2019·Frontiers in Neurology·Martin LaurenceFrédéric Calon
Jul 22, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergU Mrowietz
Aug 5, 2020·Journal of the American Academy of Dermatology·Catherine DroitcourtJacob P Thyssen
Dec 16, 2020·Journal of the American Academy of Dermatology·Jeanette Halskou HaugaardAlexander Egeberg
Jan 7, 2021·Brain Sciences·Line Buch KristensenHelle H Nielsen
Apr 17, 2021·American Journal of Clinical Dermatology·Akshitha ThatiparthiJashin J Wu
May 15, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C C von StülpnagelR Sommer
Jul 6, 2021·International Journal of Women's Dermatology·Cæcilie Bachdal JohansenSimon Francis Thomsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Investigative Dermatology
Alexander EgebergPeter Riis Hansen
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
Alexander EgebergPeter Riis Hansen
Journal of the American Academy of Dermatology
Alexander EgebergPeter Riis Hansen
© 2022 Meta ULC. All rights reserved