Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism.

Thrombosis Journal
Consuelo HuertaLuis A García Rodríguez

Abstract

Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocardial infarction (MI). The incidence rate (IR) and relative risk (RR) of MI in a cohort of patients with a diagnosis of VTE (n = 4890) compared with that of a control cohort without prior VTE (n = 43 382) were evaluated in the UK General Practice Research Database (GPRD). Death during follow-up was also determined. Patients were followed for up to 8 years (mean of 3 years). The IR of MI per 1000 person-years was 4.1 (95% CI: 3.1-5.3) for the VTE cohort and 3.5 (95% CI: 3.2-3.8) for the control cohort. The IR of MI was highest in the first year after the VTE episode, but overall differences between the two cohorts were not significant (RR of MI associated with VTE: 1.2; 95% CI: 0.9-1.6). The risk of death was higher in the VTE cohort than the control cohort, even after adjustment for cancer, heart failure and ischaemic heart disease (RR: 2.4; 95% CI: 2.2-2.6), particularly during the first year after VTE (RR: 3.8; 95% CI: 3.4-4.3). A VTE episode do...Continue Reading

References

Jul 1, 1996·Annals of Internal Medicine·P PrandoniM H Prins
Feb 26, 1997·JAMA : the Journal of the American Medical Association·S Z GoldhaberC H Hennekens
Jul 15, 1998·British Journal of Clinical Pharmacology·C R Meier, H Jick
Nov 24, 1999·Lancet·C VasilakisM del Mar Melero-Montes
Jun 10, 2000·British Journal of Clinical Pharmacology·R LawrensonR D Farmer
Apr 11, 2003·The New England Journal of Medicine·Paolo PrandoniAntonio Girolami
May 14, 2003·Pharmacotherapy·Susan S JickHershel Jick
Jun 20, 2003·Circulation·Richard H White
Jun 20, 2003·Circulation·Agnes Y Y Lee, Mark N Levine
Jul 30, 2003·Archives of Internal Medicine·Kenneth T HorlanderKenneth V Leeper
Jun 16, 2004·Circulation·Luis A García RodríguezAntonio González-Pérez
Dec 24, 2004·European Heart Journal·Cecilia BecattiniFranco Casazza
Jul 14, 2006·Journal of Thrombosis and Haemostasis : JTH·L M ReichM Cushman
Jul 20, 2006·Journal of Thrombosis and Haemostasis : JTH·W AgenoA Venco
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·P PrandoniA W A Lensing
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·P B van der HagenM Cushman

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Citations

Oct 22, 2008·Cardiovascular Ultrasound·Aguinaldo de OliveiraLiz A V Baroncini
Mar 26, 2011·Thrombosis Research·Marianne S AndresenUlrich Abildgaard
Jun 15, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fatima D MiliHarland Austin
Oct 9, 2021·Seminars in Thrombosis and Hemostasis·Steve Raoul NoumegniClément Hoffmann

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BETA
hormone replacement therapy

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STATA

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