Risk of new-onset diabetes mellitus versus reduction in cardiovascular events with statin therapy

The American Journal of Cardiology
Kang-Ling WangChern-En Chiang

Abstract

The Food and Drug Administration recently updated the safety warning concerning the association between statin therapy and new-onset diabetes mellitus (NODM). For prediabetes, little information is available for statins on cardiovascular outcome reduction and diabetogenic consequences. This study aimed to examine the risk of NODM and the reduction of cardiovascular events and death (MACE) after statin therapy in the prediabetic subjects. The medical and pharmacy claims of the prediabetic beneficiaries were retrieved from Taiwan National Health Insurance research database. The occurrence of NODM, MACE, and morbidity indexed by hospitalizations and emergency visits was ascertained by ambulatory and inpatient database. A propensity score-matched model was constructed for statin users and nonusers. During follow-up (4.1 ± 2.5 years), NODM and MACE occurred in 23.5% and 16.7%, respectively, of nonusers and 28.5% and 12.0%, respectively, of users. Statin therapy was associated with a greater risk of NODM (hazard ratio 1.20, 95% confidence interval 1.08 to 1.32) and less risk of MACE (hazard ratio 0.70, 95% confidence interval 0.61 to 0.80), both in dose-dependent fashions. The earlier and more persistent use correlated with the great...Continue Reading

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Citations

Jan 7, 2016·The American Journal of Cardiology·Seung-Woon RhaDong Joo Oh
Oct 7, 2015·Clinical Pharmacology and Therapeutics·U AnyanwaguRichard Donnelly
Dec 9, 2014·Metabolism: Clinical and Experimental·Niki KatsikiChristos S Mantzoros
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Sep 4, 2015·Therapeutic Advances in Chronic Disease·Anastazia KeiMoses Elisaf
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Apr 19, 2015·Current Opinion in Lipidology·Jennifer G Robinson
Jan 1, 2017·Metabolomics : Official Journal of the Metabolomic Society·Mona Elbadawi-SidhuRima Kaddurah-Daouk

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