Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Alejandro AranaKenneth J Rothman

Abstract

Epidemiological studies have linked domperidone use with serious cardiac arrhythmias, including sudden cardiac death, but data on age, dose, and duration of use are limited. The aim of this study was to assess the risk of out-of-hospital sudden cardiac death associated with domperidone use versus proton pump inhibitors (PPIs), metoclopramide, or non-use of all three medications, and to evaluate the risk of sudden cardiac death in relation to age and domperidone dose. This was a population-based case-control study nested in a cohort of subjects aged ≥2 years in the Clinical Practice Research Datalink with one or more prescriptions for domperidone, any PPI, or metoclopramide from 2005 to 2011. Out-of-hospital sudden cardiac death was assessed by linkage with Hospital Episode Statistics and death certificates. Controls were matched on age, sex, and medical practice. The risk of sudden cardiac death in domperidone users versus risk in users of PPIs or metoclopramide was evaluated with multivariable conditional logistic regression; case-crossover analysis addressed possible residual confounding. From the study cohort (n = 681,104), 3239 sudden cardiac death cases were matched to 12,572 controls. The adjusted odds ratio (95 % confide...Continue Reading

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Citations

Dec 10, 2015·Clinical Drug Investigation·Nattawut LeelakanokMarin L Schweizer
Oct 18, 2016·Drugs -- Real World Outcomes·Cristina Varas-LorenzoDaniel Fife
Oct 8, 2016·Digestive Diseases and Sciences·Mohammad BashashatiRichard W McCallum
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Jan 16, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joel N SwerdelPatrick B Ryan
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