PMID: 11323314Apr 27, 2001Paper

Risk of pancreatic cancer in workers exposed to chlorinated hydrocarbon solvents and related compounds: a meta-analysis

American Journal of Epidemiology
Anneli OjajärviC H Wesseling

Abstract

This is a meta-analysis of occupational exposures to chlorinated hydrocarbon (CHC) solvents and pancreatic cancer, based primarily on studies that addressed exposure directly (agent studies) and secondarily on studies that reported data without verification of individual CHC exposures (job title studies), all of which were listed in databases for the period January 1969 to May 1998. Standardized extraction of data and double-checking of consistency of data extraction by five extractors were done. Simple random models estimated meta-relative risks. Suggestive weak excesses were found for trichloroethylene (meta-relative risk (MRR) = 1.24, 95% confidence interval (CI): 0.79, 1.97), polychlorinated biphenyls (MRR = 1.37, 95% CI: 0.56, 3.31), methylene chloride (MRR = 1.42, 95% CI: 0.80, 2.53), and vinyl chloride (MRR = 1.17, 95% CI: 0.71, 1.91) but not for carbon tetrachloride. One study addressed tetrachloroethylene (MRR = 3.08, 95% CI: 0.63, 8.99); another investigated chlorohydrin production (MRR = 4.92, 95% CI: 1.58, 11.4). Exposure-response meta-analyses for trichloroethylene and methylene chloride failed to reveal trends. Job title studies on metal degreasing and dry cleaning revealed significant MRRs (2.0 and 1.4, respectiv...Continue Reading

Citations

Oct 1, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J-Matthias LöhrHeiko Witt
May 11, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Michael C R Alavanja, Matthew R Bonner
Mar 29, 2003·Journal of Occupational and Environmental Medicine·Elisabete WeiderpassEero Pukkala
Sep 9, 2006·Journal of Gastroenterology and Hepatology·Thilo WelschMarkus W Büchler
Jul 29, 2003·Occupational and Environmental Medicine·J AlguacilP Gustavsson
Apr 10, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Albert B Lowenfels, Patrick Maisonneuve
Jul 8, 2011·World Journal of Gastroenterology : WJG·Miroslav ZavoralMarek Minarik
Jul 20, 2010·European Journal of Epidemiology·Miguel SantibañezTimo Kauppinen
Mar 5, 2013·Gaceta sanitaria·Montserrat García GómezSteven Markowitz
Dec 14, 2011·Molecular Carcinogenesis·Gabriella Andreotti, Debra T Silverman
Aug 22, 2015·Cancer Causes & Control : CCC·Samuel O AntwiGloria M Petersen
Jun 18, 2002·Hematology/oncology Clinics of North America·Albert B Lowenfels, Patrick Maisonneuve
Jan 7, 2015·International Journal of Cancer. Journal International Du Cancer·Catherine C LerroLaura E Beane Freeman
Dec 17, 2014·International Journal of Epidemiology·Patrick Maisonneuve, Albert B Lowenfels
Dec 17, 2014·Environmental Science and Pollution Research International·Yoichi KawasakiToshiaki Sendo
Aug 20, 2016·Archives of Toxicology·Elisa BaroneStefano Landi
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katsuhiko YoshizawaAbraham Nyska
Jan 31, 2003·Molecular Carcinogenesis·Miquel PortaManuel Jariod

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