Risk of pancreatitis with mutation of the cystic fibrosis gene

The American Journal of Gastroenterology
C P ChoudariGlen A Lehman

Abstract

Between 5% and 15% of patients with recurrent pancreatitis have no identified etiology after routine investigation and advanced endoscopic evaluation. To determine whether mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is a risk factor for idiopathic pancreatitis. We compared the frequency of CFTR mutations as measured by DNA probe analysis in a case group of persons with idiopathic pancreatitis and a control group without pancreatitis, all of whom underwent endoscopic retrograde cholangiopancreatography. A separate analysis compared the prevalence of CFTR mutations between the case group and controls with pancreatitis of known etiology. A subgroup comparison was made between cases of pancreas divisum with pancreatitis and controls with pancreas divisum and no pancreatitis. CFTR mutations were present in 19 (19%) of 96 cases and 7 (3.5%) of 198 controls without pancreatitis (odds ratio, OR = 6.7; 95% CI, 2.8-16.3; p < 0.00001). Compared to the controls with a known cause of pancreatitis (N = 78), cases had a higher prevalence of CFTR mutations (19% vs 2.6%, OR = 9.4; CI, 2.1-41.7; p= 0.0005). Among subjects with pancreas divisum, CFTR mutations were present in 8 (22%) of 37 cases compared to 0 (...Continue Reading

References

Feb 27, 1992·The New England Journal of Medicine·S P LeeH Z Park
Jun 1, 1991·Archives of Disease in Childhood·R Scott-JuppM S Tanner
Jan 1, 1989·Digestive Diseases and Sciences·R P VenuK Soergel
Apr 28, 1994·The New England Journal of Medicine·W Steinberg, S Tenner
Oct 28, 1993·The New England Journal of Medicine·UNKNOWN Cystic Fibrosis Genotype-Phenotype Consortium
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·P B DavisM W Konstan
Feb 13, 1997·The New England Journal of Medicine·R C Stern
Sep 3, 1998·The New England Journal of Medicine·N SharerJ Braganza
Sep 3, 1998·The New England Journal of Medicine·J A CohnP S Jowell
Dec 16, 2000·Digestive Diseases and Sciences·S KimuraM Kasuga
Sep 25, 2001·The American Journal of Gastroenterology·K TruningerH E Blum

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Citations

Jan 12, 2011·Current Gastroenterology Reports·Matthew J DiMagno, Erik-Jan Wamsteker
Sep 1, 2007·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P DiMagno
Jun 5, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Matthew J DiMagnoShi-yi Zhou
Feb 21, 2008·World Journal of Gastroenterology : WJG·Volker Keim
Feb 21, 2008·World Journal of Gastroenterology : WJG·John Baillie
Sep 22, 2010·World Journal of Gastroenterology : WJG·Terumi KamisawaNaoto Egawa
Feb 20, 2007·Acta Paediatrica·Carmen A Sánchez-RamírezRocío Macías-Rosales
Oct 24, 2006·Gastrointestinal Endoscopy·John R Saltzman
Apr 25, 2006·Endocrinology and Metabolism Clinics of North America·Markus M LerchJulia Mayerle
Dec 14, 2011·The American Journal of Gastroenterology·Caroline BertinPhilippe Lévy
Feb 7, 2012·The American Journal of Gastroenterology·Matthew J DiMagno, Eugene P Dimagno
Nov 14, 2018·Biomolecular Concepts·Troy L Merry, Maxim S Petrov
Aug 8, 2006·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P Dimagno
Mar 11, 2005·Journal of Clinical Gastroenterology·Jonathan A Cohn
Oct 19, 2007·Wiener klinische Wochenschrift·Heinz ZollerWolfgang Vogel
Sep 1, 2006·Current Treatment Options in Gastroenterology·J Steven Burdick, Edward Horvath
Mar 17, 2010·Digestive Diseases and Sciences·K G SajithAmit Kumar Dutta
Apr 8, 2011·World Journal of Surgery·Lutz SchneiderJens Werner
Jun 6, 2019·Clinical and Translational Gastroenterology·David C Whitcomb, UNKNOWN North American Pancreatitis Study Group
Oct 31, 2019·Expert Review of Gastroenterology & Hepatology·Aditya GuttaStuart Sherman
Jun 5, 2018·Journal of Clinical Gastroenterology·Tom K LinAliye Uc
Apr 11, 2012·Journal of Pediatric Gastroenterology and Nutrition·Kimberly A Mackey, Douglas S Fishman
Apr 15, 2016·Pancreas·Eugene P DiMagno, Matthew J DiMagno
Apr 12, 2008·Wiener klinische Wochenschrift·Barbara Tribl
Jul 10, 2019·Frontline Gastroenterology·Mustafa JalalAndrew D Hopper
Nov 9, 2012·Journal of Digestive Diseases·Tarun Rustagi, Michael Golioto
Aug 23, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·V Keim
Aug 12, 2005·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P DiMagno
Mar 7, 2006·Gastroentérologie Clinique Et Biologique·Xavier DrayPhilippe Marteau

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