Risk of Pneumonitis After Stereotactic Body Radiation Therapy in Patients With Previous Anatomic Lung Resection

Clinical Lung Cancer
Jason T HayesMegan E Daly

Abstract

Stereotactic body radiation therapy (SBRT) has emerged as a standard treatment of early-stage, medically inoperable lung cancer. Limited data have evaluated the radiation pneumonitis (RP) risk with SBRT after previous anatomic lung resection (ALR). We assessed the incidence of RP and all pulmonary toxicity (PT) in patients who underwent lung SBRT after ALR and compared them with those of patients without previous ALR. We reviewed the medical records of 84 consecutively treated patients with stage T1-T2b non-small-cell lung cancer (NSCLC) treated with 88 courses of SBRT for 94 lung tumors from January 2007 to December 2014, including 17 patients with previous ALR. The rates of RP and all PT were compared between the patients with and without previous ALR. At a median follow-up duration of 18.3 months (range, 1.8-85.6 months), the crude grade 2+ RP rate was 5.9% and 2.8% for patients with and without previous ALR, respectively (P = .51). The corresponding 2-year estimates of freedom from RP were 89% and 97% (P = .51). The crude rate of all grade 2+ PT was 11.8% and 2.8% for those with and without previous ALR (P = .11), with 2-year estimates of freedom from PT of 97% and 84% (P = .11), respectively. The 2 cohorts were well matche...Continue Reading

References

Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·N MartiniR J Ginsberg
Feb 7, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Frank J LagerwaardUNKNOWN Rotterdam Oncological Thoracic Study Group
Jun 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Vivek Mehta
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Toshio OhashiAtsushi Kubo
Apr 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Andrew J HopeJoseph O Deasy
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Aaron M AllenElizabeth H Baldini
May 1, 2007·International Journal of Radiation Oncology, Biology, Physics·David C RiceCraig W Stevens
Sep 5, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pia BaumannRolf Lewensohn
Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Achilles J FakirisRobert Timmerman
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pia BaumannRolf Lewensohn
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
Jul 8, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthias GuckenbergerMichael Flentje
Nov 3, 2010·International Journal of Radiation Oncology, Biology, Physics·R Bryan BarrigerAchilles J Fakiris
Jun 18, 2011·The Journal of Thoracic and Cardiovascular Surgery·Kazuhiro UedaKimikazu Hamano
Nov 23, 2011·International Journal of Radiation Oncology, Biology, Physics·Frank J LagerwaardSuresh Senan
Jan 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthias GuckenbergerInga S Grills
Mar 23, 2012·International Journal of Radiation Oncology, Biology, Physics·Yukinori MatsuoMasahiro Hiraoka
Aug 30, 2012·International Journal of Radiation Oncology, Biology, Physics·Ryan BakerThomas J Dilling
Nov 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eva M BongersSuresh Senan
May 16, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Robert ThompsonAndrew Hope

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Ronald C McGarryRobert D Timmerman
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Robert D TimmermanJames Fletcher
International Journal of Radiation Oncology, Biology, Physics
Noëlle C van der Voort van ZypJoost J Nuyttens
© 2022 Meta ULC. All rights reserved