PMID: 11919244Mar 29, 2002Paper

Risk of positive margins and biochemical recurrence in relation to nerve-sparing radical prostatectomy

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Mario SoferM S Soloway

Abstract

To assess the effect of nerve-sparing (NS) radical retropubic prostatectomy (RRP) on surgical margins and biochemical recurrence. Location and incidence of positive surgical margins, recurrence, and time to recurrence were assessed in a consecutive series of 734 men who underwent RRP for localized prostate cancer from 1992 through February 2000. NS procedures were used in 33% (n = 240) of 734 patients studied. Surgical margins were positive for 24% (n = 58) and 31% (n = 152) of NS and non-NS patients, respectively (P =.06). No significant difference between the groups was found in location of positive margins (P =.92). Prostate-specific antigen level greater than 10 ng/mL, extraprostatic extension, tumor volume more than 20%, capsular penetration, Gleason score > or = 7, positive margins, and seminal vesicle invasion were associated with significantly increased risk of recurrence. However, NS patients were not at increased risk of recurrence compared with non-NS patients (hazard ratio, 0.96; 95% confidence interval, 0.53 to 1.72). The cumulative risk of recurrence within 3 and 5 years of surgery in NS patients was 9.7% and 14.4%, respectively, as compared with 17.1% and 21.1% for non-NS patients. In patients with localized pros...Continue Reading

References

Mar 11, 1992·The Journal of Urology·G F DanielsT A Stamey
Sep 1, 1982·The Journal of Urology·P C Walsh, P J Donker
Nov 1, 1996·The Urologic Clinics of North America·J I Epstein
Jun 17, 1998·The Journal of Urology·J I EpsteinP C Walsh
Nov 17, 1998·The Journal of Urology·P C Walsh

❮ Previous
Next ❯

Citations

Dec 19, 2003·The Urologic Clinics of North America·Joel B Nelson, Herbert Lepor
Mar 28, 2003·Lancet·Ashesh B Jani, Samuel Hellman
Jul 16, 2008·Prostate Cancer and Prostatic Diseases·J L NellesC J Kane
Jun 3, 2009·Prostate Cancer and Prostatic Diseases·K W KwakH Y Choi
Feb 16, 2005·Prostate Cancer and Prostatic Diseases·P Gontero, R S Kirby
Nov 24, 2011·Prostate Cancer·Qiang FuLeon Sun
Mar 13, 2013·JSLS : Journal of the Society of Laparoendoscopic Surgeons·David D ThielAlexander S Parker
Feb 19, 2010·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Joseph L ChinAndrew Evans
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·Jonathan I EpsteinRodolfo Montironi
Mar 12, 2010·Urologic Oncology·Neil E FleshnerAlexandre Zlotta
Mar 12, 2010·Urologic Oncology·Herbert Lepor, Basir Tareen
Dec 2, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Gómez CaamañoX Maldonado
Nov 2, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·L SalomonM Soulié
May 29, 2003·The Journal of Urology·Stephen J FreedlandUNKNOWN SEARCH Database Study Group
Feb 21, 2006·European Urology·Karim Touijer, Bertrand Guillonneau
May 2, 2006·European Urology·Mark S Soloway
Jan 26, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Katsunori TatsugamiUNKNOWN Japanese Society of Endourology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.