Risk of post-colonoscopy colorectal cancer due to incomplete adenoma resection: A nationwide, population-based cohort study

United European Gastroenterology Journal
Tim Dg BelderbosMartijn Gh van Oijen

Abstract

Most post-colonoscopy colorectal cancers (PC-CRCs) are thought to develop from missed or incompletely resected adenomas. We aimed to assess the incidence rate of PC-CRC overall and per colorectal segment, as a proxy for PC-CRC due to incomplete adenoma resection, and to identify adenoma characteristics associated with these PC-CRCs. We performed a nationwide, population-based cohort study, including all patients with a first colorectal adenoma between 2000-2010 in the Dutch Pathology Registry (PALGA). Outcomes were the incidence rate of PC-CRC overall and of PC-CRC in the same colorectal segment, occurring between six months and five years after adenoma resection. A multivariable Cox proportional hazard analysis was performed to identify factors associated with PC-CRCs in the same segment. We included 107,744 patients (mean age 63.4 years; 53.6% male). PC-CRC was detected in 1031 patients (0.96%) with an incidence rate of 1.88 per 1000 person years. PC-CRC in the same segment was found in 323 of 133,519 adenomas (0.24%) with an incidence rate of 0.56 per 1000 years of follow-up. High-grade dysplasia (hazard ratio (HR) 2.54, 95% confidence interval (CI) 1.99-3.25) and both villous (HR 2.63, 95% CI 1.79-3.87) and tubulovillous hi...Continue Reading

References

Feb 22, 1980·JAMA : the Journal of the American Medical Association·R A Côté, S Robboy
Dec 30, 1993·The New England Journal of Medicine·S J WinawerJ F Panish
Jul 14, 2005·Gastroenterology·Douglas J RobertsonJohn A Baron
Jan 28, 2009·Gastroenterology·María Elena MartínezE Robert Greenberg
Sep 30, 2010·The American Journal of Gastroenterology·Harminder SinghCharles N Bernstein
Jun 8, 2013·Gut·Chantal M C le ClercqSilvia Sanduleanu
Jun 19, 2013·The American Journal of Gastroenterology·Rune ErichsenHenrik Toft Sørensen
May 13, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hendrikus J M PullensPeter D Siersema
May 7, 2016·The American Journal of Gastroenterology·Jason A Dominitz, Brennan Spiegel

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Citations

Oct 16, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Fahima DossaNancy N Baxter
Apr 28, 2021·BMC Cancer·Juan Francisco Ortega-MoránFrancisco M Sánchez-Margallo
Nov 25, 2021·The American Journal of Gastroenterology·Mayenaaz SidhuMichael J Bourke

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Methods Mentioned

BETA
biopsy

Software Mentioned

SAS
Statistical Packages for Social Sciences

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