Risk of postoperative complications among ulcerative colitis patients treated preoperatively with vedolizumab: a matched case-control study

BMC Surgery
Jeong Yeon KimPhillip Fleshner

Abstract

Although biologic agents have revolutionized the medical management of severe ulcerative colitis (UC), there is considerable controversy regarding adverse effects of vedolizumab on surgical outcomes. We evaluated 30-day postoperative morbidity in UC patients undergoing abdominal colectomy (AC) treated with vedolizumab before surgery. From 2007 to 2017, 285 patients were enrolled in prospectively maintained database evaluating the role of clinical, serologic markers with clinical phenotypes in UC. The patients treated with vedolizumab within 12 weeks of AC was queried, then matched 1:3:3 into 3 preoperative treatment groups based on age, gender and surgical treatment of UC; ileal pouch-anal anastomosis (IPAA) with ileostomy vs total colectomy with end stoma: a) vedolizumab (n = 25); b) anti-tumor necrosis factor (anti-TNF) (n = 74); and c) no biologics (n = 54). Thirty-day postoperative complications among patient groups were compared. The 3 patient groups were well-matched in other characteristics including disease duration, disease extent, medication history and preoperative serological data. There were no significant differences in the overall incidence of postoperative complications among patients treated preoperatively with...Continue Reading

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Citations

Mar 7, 2021·Journal of Clinical Medicine·Abel Botelho QuaresmaPaulo Gustavo Kotze
Jun 16, 2021·Journal of Internal Medicine·Klaus R Herrlinger, Eduard F Stange
Sep 2, 2021·International Journal of Colorectal Disease·Daxin GuoBin Zhou

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