Risk of postpartum episodes in women with bipolar disorder after lamotrigine or lithium use during pregnancy: A population-based cohort study

Journal of Affective Disorders
Richard WesselooVeerle Bergink

Abstract

Women with bipolar disorder are at high risk for relapse/recurrence postpartum. Among all mood stabilizers, lithium has the largest evidence base for efficacy in the peripartum period, but lamotrigine is increasingly prescribed for bipolar spectrum disorders during pregnancy. The aim of this study was to investigate whether lamotrigine use during pregnancy is as effective as lithium in the prevention of severe episodes postpartum. Danish national registries were used to identify pregnancies of women with a diagnosis of bipolar spectrum disorders at the time of conception who used lamotrigine or lithium during pregnancy. We compared the risk of inpatient psychiatric admission within three months postpartum between women who used lamotrigine (N=55) versus lithium (N=59) during pregnancy. A logistic regression model was used to calculate crude and adjusted odds ratios. We did not find a significant difference in the risk of postpartum psychiatric admission between women who used lamotrigine versus lithium during pregnancy (7.3% versus 15.3% respectively, adjusted OR 0.83; 95% CI 0.22-3.14). We adjusted for year of delivery, parity, previous admissions and antidepressant/benzodiazepine use during pregnancy. Other variables did not ...Continue Reading

References

Jul 5, 2017·The British Journal of Psychiatry : the Journal of Mental Science·Richard WesselooVeerle Bergink

❮ Previous
Next ❯

Citations

Mar 17, 2020·Expert Review of Neurotherapeutics·Verinder SharmaSapna Sharma
Jun 12, 2020·Bipolar Disorders·Nina M MolenaarVeerle Bergink
Mar 20, 2018·Current Psychiatry Reports·Michael Thomson, Verinder Sharma
Feb 13, 2020·Focus : Journal of Life Long Learning in Psychiatry·Elizabeth AlbertiniRachel S Tamaroff
Dec 7, 2018·International Journal of Bipolar Disorders·Eline M P PoelsVeerle Bergink
Sep 1, 2017·The New England Journal of Medicine·Howard Gutgesell
Nov 9, 2019·Current Psychiatry Reports·Alison HermannAbigail Benudis
Feb 23, 2021·Expert Opinion on Pharmacotherapy·Ahmad Sleem, Rif S El-Mallakh
Mar 18, 2021·The Australian and New Zealand Journal of Psychiatry·Pavitra AranMegan Galbally

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here