Risk of preterm delivery and small-for-gestational-age births in women with autoimmune disease using biologics before or during pregnancy: a population-based cohort study

Annals of the Rheumatic Diseases
Nicole W TsaoMary A De Vera

Abstract

To assess the risk of preterm delivery and small-for-gestational-age (SGA) births in women with autoimmune diseases using biologics before or during pregnancy. Using population-based administrative data in British Columbia, Canada, women with one or more autoimmune diseases who had pregnancies between 1 January 2002 and 31 December 2012 were included. Exposure to biologics was defined as having at least one biologic prescription 3 months before or during pregnancy. Each exposed pregnancy was matched with five unexposed pregnancies using high-dimensional propensity scores (HDPS). Logistic regression modelling was used to evaluate the association between biologics use and preterm delivery and SGA. There were 6218 women with 8607 pregnancies who had an autoimmune disease diagnosis; of which 109 women with 120 pregnancies were exposed to biologics 3 months before or during pregnancy. In unadjusted analyses, the ORs for the association of biologics exposure with preterm deliveries were 1.64 (95% CI 1.02 to 2.63) and 1.34 (95% CI 0.72 to 2.51) for SGA. After HDPS matching with 600 unexposed pregnancies, the ORs for the association of biologics exposure and preterm deliveries were 1.13 (95% CI 0.67 to 1.90) and 0.91 (95% CI 0.46 to 1....Continue Reading

References

Jun 1, 1966·Journal of Chronic Diseases·I D Bross
Apr 30, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S DaherM Gerbase-DeLima
Jun 5, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Ahmed M BaharOsman A Nabri
Dec 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·X W YuX Li
Apr 21, 2006·American Journal of Epidemiology·M Alan BrookhartTil Stürmer
May 26, 2007·Nature Reviews. Immunology·Iain B McInnes, Georg Schett
Mar 6, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Olof StephanssonMette Nørgaard
Mar 3, 2011·Annals of the Rheumatic Diseases·Suzanne M M VerstappenUNKNOWN BSRBR Control Centre Consortium, BSR Biologics Register
Aug 11, 2011·Inflammatory Bowel Diseases·Fabian SchnitzlerPaul Rutgeerts
Dec 14, 2011·Autoimmunity Reviews·Monika ØstensenFrauke Förger
Jan 15, 2014·World Journal of Gastroenterology : WJG·Yi-Zhen Zhang, Yong-Yu Li
Jul 2, 2014·Alimentary Pharmacology & Therapeutics·M SeirafiY Bouhnik
Aug 12, 2014·Gastroenterology Clinics of North America·Edward V Loftus
Apr 22, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Monika Østensen, Irene Cetin
Aug 19, 2016·MMWR. Morbidity and Mortality Weekly Report·Carrie K Shapiro-MendozaPhoebe G Thorpe
Mar 23, 2017·Pediatric Emergency Care·Anand Gourishankar, KuoJen Tsao
Apr 26, 2017·Cytokine·Eugene Y Kim, Kamal D Moudgil
Sep 10, 2017·The Journal of Allergy and Clinical Immunology·Jason E HawkesJames G Krueger

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Citations

Feb 6, 2020·Pharmacoepidemiology and Drug Safety·Gabriella BrömsFredrik Granath
Nov 19, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Debra de SilvaGraham Roberts
Sep 29, 2021·Zeitschrift für Rheumatologie·Celine Häfeli, Frauke Förger

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