Risk of primary sclerosing cholangitis is associated with nonsmoking behavior

Gastroenterology
K J van ErpecumA Algra

Abstract

Seventy percent of patients with primary sclerosing cholangitis (PSC) have concomitant ulcerative colitis. Smoking and previous appendectomy may protect against ulcerative colitis. The aim of this study was to examine these factors in patients with PSC. Fifty-nine patients with PSC, 130 patients with ulcerative colitis and normal liver biochemistry, and 197 control subjects were interviewed about smoking behavior and history of appendectomy. There were less current smokers in the PSC and ulcerative colitis groups than in the control group (19%, 12%, and 38%, respectively). The resulting odds ratio for current smoking was 0.37 (95% confidence interval, (0.18-0.76) in the PSC group and 0.23 (95% confidence interval, 0.13-0.41) in the ulcerative colitis group. Percentage of persons who ever smoked was also significantly less in the PSC group (41% vs. 56% in the control group). Frequency of previous appendectomy in the PSC and ulcerative colitis groups was not significantly different from that of controls (19%, 9%, and 14%, respectively). Smoking but not previous appendectomy is associated with decreased risk of PSC.

Citations

Aug 15, 1998·Mediators of Inflammation·F J Zijlstra
Oct 26, 2006·Orphanet Journal of Rare Diseases·Joy Worthington, Roger Chapman
Jan 18, 2008·World Journal of Gastroenterology : WJG·Rebecca Saich, Roger Chapman
Jun 21, 2008·World Journal of Gastroenterology : WJG·Harry SokolPhilippe Seksik
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Annika BergquistUlrika Broomé
Sep 23, 2006·Scandinavian Journal of Gastroenterology·Jens J W TischendorfMartin Krüger
Nov 26, 2009·Expert Review of Gastroenterology & Hepatology·Crystal Knight, Karen F Murray
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N ChalasaniH Hoen
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D HowelO F James
Oct 16, 2015·Journal of Pediatric Gastroenterology and Nutrition·Andrea TencaKaija-Leena Kolho
Mar 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth Singh, Jayant A Talwalkar
Jun 17, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Kirsten BoonstraUNKNOWN Epi PSC PBC Study Group
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A BergquistU Broomé
May 5, 2012·Clinics and Research in Hepatology and Gastroenterology·Sigrid NæssTom H Karlsen
Feb 7, 2012·Clinics and Research in Hepatology and Gastroenterology·P J Trivedi, R W Chapman
Sep 17, 2003·Journal of Gastroenterology and Hepatology·J J Feld, E J Heathcote
May 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Frans van der HeideElizabeth B Haagsma
Oct 18, 2012·Alimentary Pharmacology & Therapeutics·P C Lunney, R W L Leong
Apr 6, 2004·Clinics in Liver Disease·Flavia D Mendes, Keith D Lindor
Jul 19, 2002·Gastroenterology Clinics of North America·Aruna Krishnan, Joshua R Korzenik
Dec 19, 2002·Gastrointestinal Endoscopy Clinics of North America·Christopher Huang, David R Lichtenstein
Dec 3, 2013·Journal of Hepatology·Jonas F LudvigssonShahram Bahmanyar
Oct 1, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ina Marie AndersenJohannes Roksund Hov
Jun 28, 2015·Journal of Crohn's & Colitis·Luc BiedermannUNKNOWN Swiss Inflammatory Bowel Disease Cohort Study Group
May 6, 2015·Alimentary Pharmacology & Therapeutics·D N Assis, C Levy
May 20, 2015·British Medical Bulletin·Kate D Williamson, Roger W Chapman
Apr 2, 2013·Clinics in Liver Disease·Claudia O Zein
Feb 14, 2012·Journal of Crohn's & Colitis·J S HallidayR W G Chapman
Jan 1, 1997·Inflammatory Bowel Diseases·E V LoftusN F Larusso
Sep 14, 2016·European Journal of Gastroenterology & Hepatology·Montserrat FragaUNKNOWN Swiss IBD Cohort Study Group
Sep 12, 2000·Current Gastroenterology Reports·R T PrallN F LaRusso
Jan 27, 2009·Inflammatory Bowel Diseases·Frans van der HeideGerard Dijkstra
Jul 29, 2009·Inflammatory Bowel Diseases·Ashwin N AnanthakrishnanKia Saeian
Dec 27, 2005·Inflammatory Bowel Diseases·Stephen B Hanauer
Nov 12, 2002·The American Journal of Gastroenterology·Warwick S SelbyMichael J Solomon
Aug 22, 2001·The American Journal of Gastroenterology·A H PatelW J Sandborn
Dec 21, 2004·World Journal of Gastroenterology : WJG·Piero PortincasaGerard P van Berge-Henegouwen
Mar 9, 2012·Journal of Crohn's & Colitis·Emma CalabreseStephen B Hanauer
Jul 2, 2014·International Journal of Colorectal Disease·Rajkumar Cheluvappa
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·S A Mitchell, R W Chapman
Jan 1, 2005·Inflammatory Bowel Diseases·Tanja Birrenbach, Ulrich Böcker
Mar 30, 2004·The American Journal of Gastroenterology·F MangusoA D'Arienzo
Jan 28, 2005·Inflammatory Bowel Diseases·Jayant A Talwalkar, Keith D Lindor

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