Risk of recurrent venous thromboembolism or bleeding in relation to thrombophilic risk factors in patients receiving ximelagatran or placebo for long-term secondary prevention of venous thromboembolism

British Journal of Haematology
Karin WåhlanderTHRIVE III Investigators

Abstract

The impact of prothrombotic abnormalities on the risk of recurrent venous thromboembolism (VTE) and bleeding in patients receiving long-term anticoagulation remains unclear. This analysis evaluated the influence of potential prothrombotic risk factors (antithrombin, protein C, protein S, factor V Leiden mutation, prothrombin gene G20210A mutation, cardiolipin antibodies, number of risk factors) on the risk of recurrent VTE or bleeding during treatment with oral ximelagatran (24 mg twice daily) or placebo for 18 months [THRombin Inhibitor in Venous thromboEmbolism (THRIVE) III trial]. Of the 1223 patients in the intention-to-treat population, prothrombotic state was analysed in 559 patients receiving ximelagatran and 540 patients receiving placebo. It is possible that patients at a high risk of recurrent VTE were poorly represented in this analysis because of selection bias. Prothrombotic risk factors were reported in 41% of patients (8% had > or = 2 factors). No significant interactions were found between ximelagatran treatment and potential prothrombotic risk factors for the risk of recurrent VTE or bleeding by Cox proportionate hazard modelling. There was no clear evidence for a higher risk of recurrent VTE or bleeding across...Continue Reading

References

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Mar 24, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·William M LeeSunita Sheth

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Citations

Dec 14, 2011·Revue des maladies respiratoires·F Couturaud
Aug 16, 2015·La Presse médicale·Cécile Tromeur, Francis Couturaud
Oct 12, 2013·Thrombosis Research·Anna K DonovanMargaret V Ragni
Dec 3, 2014·Gastroenterology Clinics of North America·Eric T T L TjwaErnst J Kuipers

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