Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors

Expert Opinion on Drug Metabolism & Toxicology
Simone GarzonGiovanni Monastra

Abstract

Background: D-chiro-inositol (DCI) and glucose transporter inhibitors may inhibit myo-inositol (MI) transporters, and the aim is to clinically evaluate their effect on MI absorption. Research design and methods: Fasting 18 healthy volunteers received orally 6000 mg MI, 6000 mg MI with 1000 mg DCI, and 6000 mg MI with SelectSIEVE® Apple PCQ and Sorbitol, Maltodextrin and Sucralose (PCQ-SMS), in three different phases with a washout period of 7 days. At each phase, blood samples were collected before administration, and every 60 minutes until 540 minutes after administration. MI plasma levels (μmol/L) were quantified by gas chromatography-mass spectrometry; maximum plasma concentration (Cmax), time to reach it (Tmax), and the area under the time-concentration curve of MI (AUC 0-540) were evaluated. Results: The Cmax of MI alone (Tmax = 180min) was 1.29-fold higher than those of MI with DCI (Tmax = 180min) (p < 0.001) and 1.69-fold higher than those of MI with PCQ-SMS (Tmax = 240min) (p < 0.001). The AUC 0-540 was reduced by 19.09% in MI plus DCI (p = 0.0118) and by 31.8% in MI plus PCQ-SMS (p < 0.001) as compared to MI alone. Conclusions: DCI, glucose transporter inhibitors and sugars, such as sorbitol and maltodextrin, seem to i...Continue Reading

References

Sep 21, 1989·Nature·M J Berridge, R F Irvine
Mar 20, 2002·International Journal of Experimental Diabetes Research·Joseph Larner
Jul 23, 2002·The Journal of Biological Chemistry·Michael J CoadyJean-Yves Lapointe
Dec 23, 2004·The Journal of Physiology·Francis BourgeoisJean-Yves Lapointe
Dec 30, 2004·Diabetes/metabolism Research and Reviews·Joel R L EhrenkranzJesse Roth
Oct 13, 2006·Nature·Gilbert Di Paolo, Pietro De Camilli
Jan 16, 2007·Journal of Internal Medicine·E M WrightD F Loo
Oct 13, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rym AouameurJean-Yves Lapointe
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Robert H Michell
Nov 18, 2008·Biochimica Et Biophysica Acta·Michael J Berridge
Nov 27, 2008·Archives of Biochemistry and Biophysics·Xiaobo LinRichard E Ostlund
Sep 22, 2009·Current Gastroenterology Reports·Fernando Fernández-BañaresJosep M Viver
Sep 3, 2010·Menopause : the Journal of the North American Menopause Society·Domenico GiordanoRosario D'Anna
Sep 8, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Zhijie DaiAnnie W C Kung
Aug 23, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kit-Yi LeungNicholas D E Greene
Jun 5, 2012·Urology·Rosita A CondorelliAldo E Calogero
Feb 7, 2014·Reproductive Sciences·Vittorio UnferJean-Patrice Baillargeon
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·D L Denise HofmanF J P H Fred Brouns
Mar 31, 2015·FEBS Letters·Sabine Schneider
Jul 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John E Nestler, Vittorio Unfer
Mar 2, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cristiana PaulDavid M Brady
Jun 29, 2016·Expert Opinion on Drug Metabolism & Toxicology·Mariano BizzarriArturo Bevilacqua
Aug 12, 2016·Nature Reviews. Disease Primers·Ricardo AzzizBulent O Yildiz
Sep 7, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ewa M MilewskaAlessandro D Genazzani
Nov 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Giovanni MonastraMariano Bizzarri
Jan 9, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antoaneta GatevaZdravko Kamenov
Oct 3, 2018·Trends in Endocrinology and Metabolism : TEM·Antonio Simone LaganàFabio Ghezzi
Mar 19, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicolas MendozaJuristo Fonolla

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Citations

Jun 20, 2020·Expert Opinion on Drug Metabolism & Toxicology·Antonio Simone LaganàVittorio Unfer
Sep 24, 2020·Expert Opinion on Drug Metabolism & Toxicology·Fabio FacchinettiUNKNOWN Experts Group on Inositol in Basic and Clinical Research
Apr 21, 2020·International Journal of Endocrinology·Scott Roseff, Marta Montenegro
Nov 11, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro Genazzani
Jul 3, 2021·International Journal of Molecular Sciences·Elisa LeporeVittorio Unfer
Jun 26, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mariano BizzarriAntonio Simone Laganà

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