Risk of Regional Recurrence After Negative Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence

Annals of Surgical Oncology
Ingrid G M PoodtSentinel Node and Recurrent Breast Cancer (SNARB) study group

Abstract

Repeat sentinel lymph node biopsy (rSLNB) has increasingly been used in patients with ipsilateral breast tumor recurrence (IBTR). The safety in terms of regional disease control after this procedure remains unclear. This study evaluates occurrence of regional recurrence as first event in patients with IBTR and negative rSLNB, treated without additional lymph node dissection. Data were obtained from the Sentinel Node and Recurrent Breast Cancer (SNARB) study. In 201 patients, tumor-negative rSLNB was obtained without performing additional lymph node dissections. With median follow-up of 4.7 (range 0.9-12.7) years, regional recurrence occurred after median time of 3.0 (range 0.4-6.7) years in 4.5% (N = 9) of patients as first event after IBTR and rSLNB. In four of these nine patients, the site of recurrence was in concordance with the anatomical location of rSLNB. Two of the nine recurrences were reported in the ipsilateral axilla, resulting in an ipsilateral axillary regional recurrence rate of 1.0%. In the other seven patients, regional recurrence occurred in aberrant basins. Univariable analysis showed that triple-negative IBTR and lower amount of radioactive-labeled tracer (99mtechnetium) used during rSLNB were associated wit...Continue Reading

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Citations

Jan 9, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J I Chacón López-MuñizS López-Tarruella Cobo
Mar 26, 2019·The British Journal of Surgery·I G M PoodtUNKNOWN Sentinel Node and Recurrent Breast Cancer (SNARB) study group
Mar 10, 2019·Annals of Surgical Oncology·Ingrid G M PoodtUNKNOWN Sentinel Node And Recurrent Breast Cancer (SNARB) study group
Jun 28, 2018·Annals of Surgical Oncology·Stephanie M Wong, Mehra Golshan
Apr 8, 2019·Breast Cancer Research and Treatment·Ingrid G M PoodtUNKNOWN Sentinel Node And Recurrent Breast Cancer (SNARB) Research Group

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Methods Mentioned

BETA
biopsy
dissection
irradiate

Software Mentioned

SPSS

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