Abstract
There is little published evidence examining the use of contrast material (CM) and the risk of acute renal adverse events (AEs) in individuals with increasingly common risk factors including cancer and chronic kidney disease (CKD). The objective of this study was to use real world hospital data to test the hypothesis that inpatients with cancer having CT procedures with iodinated CM would have higher rates of acute renal AEs in comparison to inpatients without cancer. Inpatient hospital visits in the Premier Hospital Database from January 1, 2010 through September 30, 2015 were eligible for inclusion. The outcome of interest was a composite of acute renal AEs including: acute kidney injury, acute renal failure requiring dialysis, contrast induced-acute kidney injury and renal failure. Multivariable models, adjusted for differences in patient demographics and comorbid conditions, were used to estimate the incremental risk of acute renal AEs by CT (with or without iodinated CM), CKD stage and type of cancer. Among 29,850,475 inpatient visits across 611 hospitals, 7.4% had record of a CT scan, 5.9% had CKD, and 3.4% had the primary diagnosis of cancer. The baseline risk for an acute renal AE in patients without cancer or CKD and n...Continue Reading
References
Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Jul 27, 2001·European Radiology·S K Morcos, H S Thomsen
Jan 14, 2005·Allergy·K BrockowUNKNOWN EAACI interest group on drug hypersensitivity
Apr 14, 2006·Kidney International. Supplement·R Mehran, E Nikolsky
Feb 28, 2007·Leukemia & Lymphoma·V Eleutherakis-PapaiakovouUNKNOWN Greek Myeloma Study Group
May 3, 2008·Leukemia & Lymphoma·Morie A Gertz
Jun 6, 2008·Leukemia·M A DimopoulosH Ludwig
Jul 24, 2008·AJR. American Journal of Roentgenology·Jeffrey H NewhouseJustin Starren
Oct 15, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jay P Heiken
May 5, 2010·Journal of the American College of Radiology : JACR·Brendan McMenomyDavid Hunter
Apr 23, 2011·AJR. American Journal of Roentgenology·Jay K PahadeIvan Pedrosa
Jun 23, 2012·Oncology·Tomohiro MizunoKiyofumi Yamada
Dec 18, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Abdulla K SalahudeenPankaj Shah
Apr 13, 2013·Radiology·Matthew S DavenportJames H Ellis
May 21, 2013·Journal of the Chinese Medical Association : JCMA·Ming-Kun HuangMu-Shun Huang
May 29, 2013·European Journal of Radiology·Shira I MoosShandra Bipat
Nov 14, 2013·European Radiology·Irfan CicinSedat Ustundag
Jan 18, 2014·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Wendy BottinorIon Jovin
Feb 25, 2014·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Richard J OwenBrendan J Barrett
May 16, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Frank R ErnstAlpesh N Amin
Jul 27, 2014·The Oncologist·Alberto FarolfiGiampaolo Gavelli
Sep 10, 2014·Radiology·Robert J McDonaldEric E Williamson
Nov 2, 2014·BMC Cancer·Alberto FarolfiGiampaolo Gavelli
Aug 5, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Seok-In HongJae-Lyun Lee
Sep 6, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laura CosmaiMark A Perazella
Feb 3, 2016·Annals of Internal Medicine·John EngEric B Bass
Aug 5, 2017·Journal of Cellular Physiology·Irene TerrenatoStefano Canitano