Risk of Respiratory Syncytial Virus Infection in Cyanotic Congenital Heart Disease in a Subtropical Area

The Journal of Pediatrics
Shuenn-Nan ChiuMei-Hwan Wu

Abstract

To compare the risk of respiratory syncytial virus (RSV)-associated hospitalization and analyze the epidemiology of RSV infection in patients with cyanotic and acyanotic congenital heart disease (CHD), we analyzed the nationwide health insurance database from 2005-2010. This study included 1050 patients with cyanotic CHD and 7077 patients with acyanotic CHD. Patients with acyanotic CHD were further classified into hemodynamically significant (hs)-acyanotic and non-hs-acyanotic groups according to whether they underwent surgery or took at least 2 anticongestive medications. RSV-associated hospitalization was higher in the cyanotic group than in hs-acyanotic and non-hs-acyanotic groups both before 1 year of age (4.8% vs 2.1% vs 1.5%, P < .001) and between 1 and 2 years of age (0.9% vs 0.56% vs 0.14%, P = .003). The hospitalization duration, intensive care, ventilator support prevalence, hospitalization cost, and mortality rate were significantly higher in the cyanotic group than in the other 2 groups. Logistic regression revealed that cyanotic CHD was the most significant risk factor for the ventilator support and RSV-associated mortality. In both patients with cyanotic and acyanotic CHD, RSV-associated hospitalization rate was h...Continue Reading

References

Apr 3, 2003·The Pediatric Infectious Disease Journal·Lone Graff StensballeEric A Simoes
Sep 2, 2003·Pediatrics·Dario PraisUNKNOWN Israeli Respiratory Syncytial Virus Monitoring Group
Dec 3, 2004·Pediatrics·Laura E Yount, William T Mahle
Oct 9, 2009·Journal of Medical Economics·Mark NuijtenWolfgang Wittenberg
Feb 6, 2010·PharmacoEconomics·William A PrescottJoseph A Paladino
Feb 9, 2010·The Journal of Pediatrics·Mei-Hwan WuSan-Kuei Huang
Jul 27, 2010·Journal of Medical Economics·Kelly A SmartBosco A Paes
Jul 30, 2010·Current Medical Research and Opinion·Robert C WelliverCaroline B Hall
Feb 9, 2011·Archives of Pediatrics & Adolescent Medicine·Christian HamppAlmut G Winterstein
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chi-Chun SungFu-Yuan Huang
Jun 15, 2011·The Canadian Journal of Cardiology·Kevin C HarrisDerek G Human
Jan 14, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D HervásJ A Hervás
Jul 30, 2014·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Infectious Diseases, UNKNOWN American Academy of Pediatrics Bronchiolitis Guidelines Committee
Oct 17, 2015·Clinical Microbiology : Open Access·Tonya M ThompsonJohn P DeVincenzo

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Citations

Apr 30, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B ReschA Gamillscheg
Dec 5, 2017·Cardiology in the Young·Indah K MurniTrevor Duke

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