Risk of second malignancy after non-Hodgkin's lymphoma: a British Cohort Study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Nadejda Y MudieDavid C Linch

Abstract

To assess long-term site-specific risks of second malignancy following non-Hodgkin's lymphoma (NHL) in relation to treatment and demographic factors. A cohort of 2,456 patients with NHL who were first treated from 1973 to 2000 and were younger than 60 years from centers in the British National Lymphoma Investigation were observed, and occurrences of second malignancy was compared with expectations based on general population cancer rates in England and Wales. In total, 123 second malignancies occurred. Relative risks (RRs) were significantly elevated for all malignancies combined (RR = 1.3; 95% CI, 1.1 to 1.6) and for leukemia (RR = 8.8; 95% CI, 5.1 to 14.1) and lung cancer (RR = 1.6; 95% CI, 1.1 to 2.3). RRs of malignancy overall diminished significantly with increasing age at first treatment. Leukemia risk was significantly increased after chemotherapy (RR = 10.5; 95% CI, 5.0 to 19.3) and mixed-modality treatment (RR = 13.0; 95% CI, 5.2 to 26.7). Relative risks of lung (RR = 1.9; 95% CI, 1.1 to 3.1) and colorectal (RR = 2.1; 95% CI, 1.1 to 3.6) cancers were significantly raised following chemotherapy. NHL patients are at elevated risk of developing second malignancy, particularly leukemia and lung cancer. The relative risk is...Continue Reading

References

May 1, 1992·Cancer·L B TravisE S Jaffe
May 1, 1991·Hematological Oncology·M LishnerS Sutcliffe
Apr 1, 1991·Cancer·L B TravisJ F Fraumeni
Jan 4, 1990·The New England Journal of Medicine·J M KaldorS Karjalainen
Jan 4, 1990·The New England Journal of Medicine·J M KaldorD Assouline
Apr 21, 1988·The New England Journal of Medicine·J Pedersen-BjergaardM M Hansen
Sep 15, 1981·Cancer·B K MacDougallS Kemel
May 17, 1995·Journal of the National Cancer Institute·J F BoivinP Mauch
Apr 5, 1995·Journal of the National Cancer Institute·L B TravisJ Adami
Oct 5, 1994·Journal of the National Cancer Institute·L B TravisP M Banks
Dec 1, 1993·Journal of the National Cancer Institute·L B TravisP Inskip
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L B TravisJ D Boice
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J SwerdlowD C Linch
Feb 7, 2001·British Journal of Cancer·P BrennanP Boffetta
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J SwerdlowD C Linch
Feb 7, 2002·Journal of the National Cancer Institute·Lois B TravisEthel Gilbert
May 9, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C HosingI F Khouri
May 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·A J Swerdlow

❮ Previous
Next ❯

Citations

Nov 15, 2006·Pediatric Surgery International·R E BrughaK Lakhoo
Aug 30, 2011·World Journal of Pediatrics : WJP·Moustafa HamchouAhmed H Al-Salem
Mar 4, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael G Moore, Neil Bhattacharyya
Mar 27, 2013·Nature Reviews. Clinical Oncology·Lois B TravisAndrea K Ng
Feb 12, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PiraniS Sacchi
Apr 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M VarettoniE Morra
Mar 12, 2013·Japanese Journal of Clinical Oncology·Nobuhiro HiramotoKensei Tobinai
Feb 9, 2012·Journal of the National Cancer Institute·Lois B TravisJohn D Boice
Jul 14, 2009·Current Opinion in Oncology·Daniel O Persky, Thomas P Miller
Jan 1, 2014·Health Physics·Lois B TravisJohn D Boice
Nov 11, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Suhail Al-Salam, Moueid Al-Ashari
Sep 26, 2012·The Cancer Journal·Laurie H Sehn
Apr 27, 2013·Journal of Medical Case Reports·Ying YuanXian Zhong
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lindsay M MortonJoseph F Fraumeni
Nov 2, 2011·The Oncologist·Ari M VanderWalde, Arti Hurria
Feb 16, 2011·Journal of the American Veterinary Medical Association·Laura MarconatoEric Zini
Apr 24, 2012·Croatian Medical Journal·Mateja JankovićAriana Znaor
Jul 12, 2011·Leukemia & Lymphoma·Chen LossosIzidore S Lossos
Sep 23, 2014·Expert Opinion on Drug Delivery·Christopher M Knapp, Kathryn A Whitehead
Feb 18, 2014·British Journal of Haematology·Justo Lorenzo BermejoKari Hemminki
May 15, 2015·Journal of Cancer Research and Clinical Oncology·Sheng-Hsuan ChienCheng-Hwai Tzeng
Jan 31, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V A MorrisonS M Lichtman
Jun 21, 2014·Neuro-oncology·Jun WangPatrick B Johnston
Jan 7, 2014·PloS One·Hui-Jen TsaiJeffrey S Chang
Apr 3, 2012·Critical Reviews in Oncology/hematology·Stephanie A Terezakis, Yvette L Kasamon
Feb 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea K NgJoachim Yahalom
Dec 31, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip SavageAnthony Swerdlow
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincenzo PitiniGiuseppe Altavilla
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carrie A ThompsonBrian K Link
Mar 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kari HemminkiJusto Lorenzo Bermejo
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie E WoodLois B Travis
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea K NgLois B Travis
Sep 28, 2013·Clinical Lymphoma, Myeloma & Leukemia·Enrica MorraMario Cazzola
Jun 27, 2007·Seminars in Radiation Oncology·Theodore Girinsky, Mithra Ghalibafian
Nov 28, 2016·Hematology/oncology Clinics of North America·Eva Giné, Laurie H Sehn
Jun 7, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Constantin A DasanuJonessa A Atienza

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