Risk of second primary cancer following prostate cancer radiotherapy: DVH analysis using the competitive risk model

Physics in Medicine and Biology
R TakamE E Yeoh

Abstract

This study aimed to estimate the risk of developing second primary cancer (SPC) corresponding to various radiation treatment techniques for prostate cancer. Estimation of SPC was done by analysing differential dose-volume histograms (DDVH) of normal tissues such as rectum, bladder and urethra with the competitive risk model. Differential DVHs were obtained from treatment planning systems for external beam radiotherapy (EBRT), low-dose-rate (LDR) and high-dose-rate (HDR) brachytherapy techniques. The average risk of developing SPC was no greater than 0.6% for all treatment techniques but was lower with either LDR or HDR brachytherapy alone compared with any EBRT technique. For LDR and HDR brachytherapy alone, the risk of SPC for the rectum was 2.0 x 10(-4)% and 8.3 x 10(-5)% respectively compared with 0.2% for EBRT using five-field 3D-CRT to a total dose of 74 Gy. Overall, the risk of developing SPC for urethra following all radiation treatment techniques was very low compared with the rectum and bladder. Treatment plans which deliver equivalent doses of around 3-5 Gy to normal tissues were associated with higher risks of development of SPC.

References

Oct 20, 1999·Cancer·F LeviC La Vecchia
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·S Nag, N Gupta
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·R J Yaes
Jul 4, 2002·Journal of the National Cancer Institute·Ruth EtzioniEric J Feuer
Dec 5, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tom Pickles, Norm Phillips
Mar 12, 2003·The Journal of Urology·Camilla ThellenbergHenrik Grönberg
Mar 28, 2003·Lancet·Ashesh B Jani, Samuel Hellman
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Eric J Hall, Cheng-Shie Wuu
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Yasuo YoshiokaToshihiko Inoue
Dec 20, 2003·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Rachana SinghAshesh B Jani
Apr 2, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas MartinNikolaos Zamboglou
Sep 9, 2004·Radiation Protection Dosimetry·F VanhavereL Struelens
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Uwe SchneiderBarbara Kaser-Hotz
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Stephen F KryIsaac I Rosen
Apr 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Eric J Hall
Aug 1, 2006·Cancer·Kihyuck MoonDan Theodorescu
Aug 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Stanley L LiauwPeter D Grimm
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Eric E YeohPrasad Abeysinghe
Jan 30, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David B MansurBeth P Maserang
Jan 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Jeremy D RubenAlistair Hunter
Feb 9, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wolfgang Dörr, Thomas Herrmann
Jun 10, 2008·Physics in Medicine and Biology·X George XuHarald Paganetti

❮ Previous
Next ❯

Citations

Sep 22, 2010·Australasian Physical & Engineering Sciences in Medicine·Svetlana Sjostedt, Eva Bezak
Jun 16, 2012·Computational and Mathematical Methods in Medicine·Zdenka KuncicSébastien Incerti
Jul 10, 2013·Radiation Oncology·Louise MurrayUNKNOWN BRAPHYQS/PROBATE group of the GEC ESTRO
Nov 10, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Johanne HermessePhilippe Nickers
May 12, 2012·Urologic Oncology·Michael R AbernChristopher L Coogan
Jan 8, 2015·Radiation Protection Dosimetry·Eva BezakLoredana G Marcu
Oct 19, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jiayi HuangFrank A Vicini
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Alexandru DaşuPer Nilsson
Jan 2, 2010·International Journal of Radiation Oncology, Biology, Physics·Ryan J BurriRichard G Stock
Apr 4, 2014·The Lancet Oncology·Ross HalperinTom Pickles
Jul 3, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Louise MurrayUNKNOWN UroGEC/BRAPHYQS group of the GEC ESTRO
Dec 22, 2016·The New England Journal of Medicine·Theodore S HongLawrence R Zukerberg
Jun 26, 2010·Physics in Medicine and Biology·Ndimofor ChoforBjörn Poppe
Jan 18, 2018·Asia-Pacific Journal of Clinical Oncology·Melissa JamesMa Yi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Tom Pickles, Norm Phillips
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Wolfgang Dörr, Thomas Herrmann
International Journal of Radiation Oncology, Biology, Physics
Jeremy D RubenAlistair Hunter
© 2021 Meta ULC. All rights reserved