PMID: 9416985Jan 7, 1998Paper

Risk of serious adverse events in hypertensive patients receiving isradipine: a meta-analysis

Journal of Human Hypertension
S D RossI E Allen

Abstract

A meta-analysis was performed to compare the risk of serious adverse events associated with the use of all formulations of isradipine, when used as monotherapy in hypertension, to active drug or placebo controls. Eligible studies totalled 65 published and unpublished randomised controlled trials involving 9903 subjects and 10,675 treatment exposures: 4492 to isradipine, 1473 to isradipine sustained release, 2768 to other active drugs, and 1942 to placebo. Mortality, cardiovascular outcomes, other serious incident illnesses, such as cancer, and withdrawals were sought. Seventy-five per cent of the isradipine exposures were to standard-release formulations and 25% were to sustained-release formulations. Overall, isradipine therapy shows no difference in risk of major adverse events or withdrawals compared to other active controls or placebo (odds ratios [OR] 0.9; 95% CI 0.7-1.46 and 0.5; 95% CI 0.2-1.3). These major adverse events included angina, fatal and non-fatal myocardial infarction, stroke and overall mortality. Isradipine sustained release could be compared only to placebo, based on available data, and shows a lower risk of withdrawals (OR 0.5; 95% CI 0.3-0.9), and a similar trend was observed for major adverse events, (O...Continue Reading

Citations

Jul 8, 2003·Current Hypertension Reports·George S Chrysant, Steven G Chrysant
May 5, 2012·BMC Medical Research Methodology·Fiona C WarrenAlex J Sutton
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J P A IoannidisA N Freedman
May 12, 2010·Journal of Clinical Epidemiology·Su GolderMartin Bland
Apr 25, 2006·Surgical Oncology Clinics of North America·Steven O'Day, Peter Boasberg

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