Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study

Pharmacoepidemiology and Drug Safety
Catherine B JohannesDaniel Fife

Abstract

Limited information from spontaneous reports and results of two case-control studies raised concern about the cardiotoxicity of oral domperidone therapy. This case-control study nested in a retrospective cohort evaluated the combined risk of serious ventricular arrhythmia (SVA) and sudden cardiac death (SCD) in users of domperidone compared with users of proton pump inhibitors (PPIs), or non-users of these medications. A cohort of users of domperidone or a PPI from 1990 to 2005 was identified from existing electronic databases of Saskatchewan Health. Possible cases of SVA/SCD were identified using hospital discharge and vital statistics codes. SVA cases were validated by cardiologist review of abstracted hospital medical charts. Up to four controls were matched to each case by index date, year of birth, sex, and diabetes status. The odds ratio (OR) of current domperidone exposure relative to non-use or to current PPI exposure was estimated and adjusted for possible confounding variables using conditional logistic regression. From 83 212 individuals in the exposure cohort we identified 1608 cases, 49 SVA and 1559 SCD (mean age 79.4 years, females 52.9%, diabetes 22.3%) and 6428 matched controls. The adjusted OR for SVA/SCD with ...Continue Reading

References

Aug 17, 1985·Lancet·R J OsborneJ Hamer
Jan 12, 1985·British Medical Journal·H A CameronG Lake-Bakaar
Nov 1, 1985·Human Toxicology·R J OsborneJ Hamer
May 1, 1982·Lancet·R A JossR L Galeazzi
Dec 8, 1984·British Medical Journal·J B RoussakH Parry
Dec 26, 2001·Archives of General Psychiatry·W A RayK T Murray
May 10, 2002·Pharmacoepidemiology and Drug Safety·K J Rothman, W Ray
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Sep 10, 2004·The New England Journal of Medicine·Wayne A RayC Michael Stein
Feb 4, 2005·Pediatric Cardiology·C M G Rocha, M M Barbosa
May 13, 2005·European Heart Journal·Sabine M J M StrausBruno H Ch Stricker
Jul 28, 2006·British Journal of Clinical Pharmacology·Marie L De BruinArno W Hoes
Sep 26, 2006·Current Opinion in Pharmacology·Naveed AhmadThomas Abell
Jan 16, 2009·The New England Journal of Medicine·Wayne A RayC Michael Stein
May 15, 2009·The New England Journal of Medicine·Ross J Baldessarini

❮ Previous
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Citations

Jul 17, 2013·Drugs·Christoph SchroederHoracio Kaufmann
Nov 10, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jordi CastellsagueUNKNOWN Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project
Jul 25, 2013·American Journal of Veterinary Research·Jorge E NietoJack R Snyder
Nov 19, 2013·Rheumatology·Alessandra VaccaUNKNOWN Scleroderma Clinical Trial Consortium Cardiac Subcommittee
Sep 26, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mahmoud H MosliMajid Al-Madi
Mar 1, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J-S ChoiG Koren
Oct 24, 2013·Expert Opinion on Drug Safety·Sheila A Doggrell, Jules C Hancox
Apr 2, 2015·The American Journal of the Medical Sciences·Arleen OrtizRichard W McCallum
Dec 10, 2015·Clinical Drug Investigation·Nattawut LeelakanokMarin L Schweizer
Jan 25, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S Prot-LabartheO Bourdon
Jun 23, 2015·Pharmacoepidemiology and Drug Safety·Hung-Lin Chen, Fei-Yuan Hsiao
Jun 10, 2016·CMAJ Open·Kate SmolinaBarbara Mintzes
Jul 26, 2016·Canadian Journal of Gastroenterology & Hepatology·Nauzer ForbesTed Xenodemetropoulos
Jan 5, 2011·British Journal of Pharmacology·Peter V Dicpinigaitis
Jan 25, 2012·Pharmacoepidemiology and Drug Safety·Joshua J GagneSebastian Schneeweiss
Sep 10, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alejandro AranaKenneth J Rothman
Apr 3, 2015·Pharmacoepidemiology and Drug Safety·Catherine HillBruno Toussaint
Jun 29, 2014·BMJ Case Reports·Om Prakash DhakalDhurba Bhandari
Mar 26, 2013·Parkinsonism & Related Disorders·Naveed M MalekDonald G Grosset
Apr 1, 2016·Expert Opinion on Drug Safety·Richard McCallumMohammad Bashashati
Jun 15, 2016·Pharmacoepidemiology and Drug Safety·Kate SmolinaSteven G Morgan
Jan 24, 2016·Postgraduate Medical Journal·Adam IoannouConstantinos Missouris
Apr 12, 2016·British Journal of Clinical Pharmacology·Christel RenouxUNKNOWN Canadian Network for Observational Drug Effect Studies (CNODES) investigators
Oct 18, 2016·Drugs -- Real World Outcomes·Cristina Varas-LorenzoDaniel Fife
Sep 21, 2013·Parkinsonism & Related Disorders·Antoniya Todorova, K Ray Chaudhuri
Oct 8, 2016·Digestive Diseases and Sciences·Mohammad BashashatiRichard W McCallum
Dec 3, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Luc M Hondeghem, Noël H Logghe
Dec 19, 2016·Revue D'épidémiologie Et De Santé Publique·M RochoyUNKNOWN Réseau français des centres régionaux de pharmacovigilance
Feb 26, 2016·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Barbara HaaseCarol L Wagner
Oct 17, 2014·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Luke Grzeskowiak
Apr 15, 2015·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Catherine PaulDavid Balayssac
Apr 15, 2015·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Luke E Grzeskowiak, Lisa H Amir
Sep 8, 2017·Current Treatment Options in Gastroenterology·Allen A Lee, William L Hasler
Apr 18, 2013·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Jack Newman
Nov 8, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Heckert, H P Parkman
Feb 15, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J R GiudicessiM Camilleri
Aug 15, 2018·Pharmacoepidemiology and Drug Safety·Azar MehrabadiKristian B Filion
Sep 6, 2013·The American Journal of Gastroenterology·Michael Camilleri, Henry Parkman
Dec 18, 2018·Basic & Clinical Pharmacology & Toxicology·Ignacio Aznar-LouAnton Pottegård
Jul 18, 2019·Expert Review of Gastroenterology & Hepatology·Mohammed ShakhatrehHenry P Parkman
Aug 29, 2014·The Medical Journal of Australia·Luke E Grzeskowiak, Lisa H Amir

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