Risk of severe maternal morbidity associated with in vitro fertilisation: a population-based study

BJOG : an International Journal of Obstetrics and Gynaecology
C Le RayEpimoms Study Group

Abstract

To investigate the association between in vitro fertilisation IVF and severe maternal morbidity (SMM) and to explore the role of multiple pregnancy as an intermediate factor. Population-based cohort-nested case-control study. Six French regions in 2012/13. Cases were 2540 women with SMM according to the EPIMOMS definition; controls were 3651 randomly selected women who gave birth without SMM. Analysis of the associations between IVF and SMM with multivariable logistic regression models, differentiating IVF with autologous oocytes (IVF-AO) from IVF with oocyte donation (IVF-OD). The contribution of multiple pregnancy as an intermediate factor was assessed by path analysis. Severe maternal morbidity overall and SMM according to its main underlying causal condition and by severity (near misses). The risk of SMM was significantly higher in women with IVF (adjusted OR = 2.5, 95% CI 1.8-3.3). The risk of SMM was significantly higher with IVF-AO, for all-cause SMM (aOR = 2.0, 95% CI 1.5-2.7), for near misses (aOR = 1.9, 95% CI 1.3-2.8), and for intra/postpartum haemorrhages (aOR = 2.3, 95% CI 1.6-3.2). The risk of SMM was significantly higher with IVF-OD, for all-cause SMM (aOR = 18.6, 95% CI 4.4-78.5), for near misses (aOR = 18.1, 95...Continue Reading

References

Mar 3, 2004·Obstetrics and Gynecology·Rebecca A JacksonMary S Croughan
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Donna A Wiggins, Elliott Main
Nov 2, 2005·Obstetrics and Gynecology·Tracy ShevellMary E D'Alton
May 20, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·J J ZwartJ van Roosmalen
Jan 12, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bengt KällénPetra Olausson Otterblad
May 8, 2010·American Journal of Ophthalmology·Kristina TornqvistPetra Otterblad Olausson
Mar 4, 2011·Journal of Neuroradiology. Journal De Neuroradiologie·UNKNOWN Société Française de NeuroradiologieUNKNOWN Agence de la Biomédecine
May 23, 2012·Journal de gynécologie, obstétrique et biologie de la reproduction·B BlondelUNKNOWN National Coordination Group of the National Perinatal Surveys
Jun 8, 2012·Reproductive Biology and Endocrinology : RB&E·Dominic StoopPaul Devroey
Jun 21, 2012·Seminars in Perinatology·Brett C Young, Blair J Wylie
Feb 15, 2014·BMC Pregnancy and Childbirth·Noriyoshi WatanabeHaruhiko Sago
Mar 8, 2014·Fertility and Sterility·Lucky H SekhonNathan S Fox
Mar 25, 2014·American Journal of Obstetrics and Gynecology·Yacov LevronYoav Yinon
Jun 12, 2014·Human Reproduction Update·Jemma EvansLuk J F Rombauts
Dec 4, 2015·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Saswati SunderamWanda D Barfield
Dec 10, 2015·Obstetrics and Gynecology·Angela S MartinSheree L Boulet
Feb 9, 2016·Obstetrics and Gynecology·Candice BelanoffJudy E Stern
Apr 12, 2016·Fertility and Sterility·Erica T WangMargareta D Pisarska
Sep 7, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·M StorgaardA Pinborg
Dec 17, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·L T NyfløtS Vangen
Mar 12, 2017·Fertility and Sterility·Lucie GuilbaudCamille Le Ray
Mar 16, 2017·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org, UNKNOWN Practice Committee of the Society for Assisted Reproductive Technology
Apr 22, 2017·American Journal of Obstetrics and Gynecology·Cande V Ananth, Enrique F Schisterman
Jun 7, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·A CromiF Ghezzi

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Citations

Dec 18, 2020·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Saswati SunderamWanda D Barfield

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