Risk of Stroke After Colorectal Surgery for Cancerous Versus Benign Conditions

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Greeshma Rajeev-KumarMandip S Dhamoon

Abstract

Cancer treatment, specifically surgical intervention, as a possible stroke trigger is understudied. Using the Nationwide Readmissions Database and validated diagnosis and procedure codes, we identified adults with index admissions for colorectal surgery for colorectal adenocarcinoma (Group A) and compared them to admissions for colorectal surgery for benign conditions (Group B) and hepatobiliary or pancreatic surgery for benign conditions (Group C). Within the colorectal cancer cohort, we further identified patients who underwent open versus laparoscopic surgery. The primary outcome was readmission for ischemic or hemorrhagic stroke up to 1 year. Cumulative risk of ischemic stroke was calculated using risk survival statistics, and hazard ratios (HR) were calculated using adjusted Cox regression. Patients in Group A had higher 3-month readmission rates for ischemic and hemorrhagic strokes than those in Groups B and C. Higher risk of ischemic stroke (HR 1.46, 95% confidence interval [CI] 1.20-1.79) in Group A compared to Group B was eliminated following adjustments for illness severity and vascular risk factors. Comparing types of colorectal surgical intervention for cancer, there was significantly greater risk of ischemic stroke...Continue Reading

Citations

Mar 19, 2021·International Heart Journal·Taro TakeuchiUNKNOWN Osaka Acute Coronary Insufficiency Study (OACIS) Group

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